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1288. Phase 1 First-in-Human Single- and Multiple-Ascending Dose Trial Demonstrates Pharmacokinetics (PK) and Tolerability of SPR720, an Oral DNA GyrB Inhibitor for Mycobacterial Infections

BACKGROUND: SPR720 (phosphate pro-drug of SPR719) is a novel aminobenzimidazole bacterial DNA gyrase (GyrB) inhibitor in development for non-tuberculous mycobacterial lung disease (NTM-LD) and pulmonary tuberculosis. SPR719 has broad-spectrum activity versus clinically relevant mycobacteria in vitro...

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Detalles Bibliográficos
Autores principales:	Talley, Angela, Thurston, Archie, Moore, Grayson, Satterfield, Myriah M, Manyak, Erika L, Kumar, Vipul, Stokes, Suzanne, Dane, Aaron, Melnick, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Poster Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777491/ http://dx.doi.org/10.1093/ofid/ofaa439.1471

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