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479. Mobility Restrictions and COVID-19 Pandemic Outbreak Control

BACKGROUND: In December 2009, a cluster of patients with pneumonia was reported in the city of Wuhan, capital of Hubei province in China, caused by a novel coronavirus: SARS-CoV-2. The epidemiological compartmental susceptible-exposed-infected-recovered (SEIR) model has been previously used during t...

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Autores principales: Starling, Carlos Ernesto Ferreira, Marinho Couto, Bráulio Roberto Gonçalves, da Cunha Júnior, Joaquim José, Alvim, André Luiz, Oliveira, Cristóvão de Deus Martins, Souza, Gregory Lauar, de Carvalho, Handerson Dias Duarte, Rocha, Rhayssa Fernanda Andrade
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777597/
http://dx.doi.org/10.1093/ofid/ofaa439.672
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author Starling, Carlos Ernesto Ferreira
Marinho Couto, Bráulio Roberto Gonçalves
da Cunha Júnior, Joaquim José
Alvim, André Luiz
Oliveira, Cristóvão de Deus Martins
Souza, Gregory Lauar
de Carvalho, Handerson Dias Duarte
Rocha, Rhayssa Fernanda Andrade
author_facet Starling, Carlos Ernesto Ferreira
Marinho Couto, Bráulio Roberto Gonçalves
da Cunha Júnior, Joaquim José
Alvim, André Luiz
Oliveira, Cristóvão de Deus Martins
Souza, Gregory Lauar
de Carvalho, Handerson Dias Duarte
Rocha, Rhayssa Fernanda Andrade
author_sort Starling, Carlos Ernesto Ferreira
collection PubMed
description BACKGROUND: In December 2009, a cluster of patients with pneumonia was reported in the city of Wuhan, capital of Hubei province in China, caused by a novel coronavirus: SARS-CoV-2. The epidemiological compartmental susceptible-exposed-infected-recovered (SEIR) model has been previously used during the initial wave of the H1N1 influenza pandemic in 2009. This study investigates whether the SEIR model, associated to mobility changes parameters, can determine the likelihood of establishing control over an epidemic in a city, state or country. METHODS: The critical step in the prediction of COVID-19 by a SEIR model are the values of the basic reproduction number (R0) and the infectious period, in days. R0 and the infectious periods were calculated by mathematical constrained optimization, and used to determine the numerically minimum SEIR model errors in a country, based on COVID-19 data until april 11(th). The Community Mobility Reports from Google Maps (https://www.google.com/covid19/mobility/) provided mobility changes on april 5(th) compared to the baseline (Jan 3(th) to Feb 6(th)). The data was used to measure the non-pharmacological intervention adherence. The impact of each mobility component was made by logistic regression models. COVID-19 control was defined by R0 of the SEIR model in a country less than 1.0. Algorithm for the SEIR model applied to COVID-19 (initialization) [Image: see text] Table 01: Algorithm for the SEIR model applied to COVID-19 (calculation of new COVID-19 cases day-by-day) [Image: see text] RESULTS: Residential mobility restriction presented the higher logistic coefficient (17.7), meaning higher impact on outbreak control. Workplace mobility restriction was the second most effective measure, considering a restriction minimum of 56% for a 53% chance of outbreak control. Retail and recreation mobility presented 53%, and 86% respectively. Transit stations (96% and 54%) were also assessed. Park mobility restriction demonstrated the lowest effectiveness in outbreak control, considering that absolute (100%) restriction provided the lowest chance of outbreak control (46%). Table 2: The Community Mobility Reports from Google Maps: Mobility changes on April 5 compared to the baseline (5- week period; Jan 3–Feb 6, 2020): T_infectious and R0 obtained by using COVID-19 new cases day-by-day in each country, adjusted to the SEIR model by mathematical constrained optimization [Image: see text] Logistic regression models to evaluate the chance of an epidemic control based on the non-pharmacological interventions adherence [Image: see text] Simulation of the impact of the mobility component in the chance of outbreak control: analysis by using the logistic regression model summarized in Table 2 [Image: see text] CONCLUSION: Residential mobility restriction is the most effective measure. The degree to which mobility restrictions increase or decrease the overall epidemic size depends on the level of risk in each community and the characteristics of the disease. More research is required in order to estimate the optimal balance between mobility restriction, outbreak control, economy and freedom of movement. DISCLOSURES: All Authors: No reported disclosures
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spelling pubmed-77775972021-01-07 479. Mobility Restrictions and COVID-19 Pandemic Outbreak Control Starling, Carlos Ernesto Ferreira Marinho Couto, Bráulio Roberto Gonçalves da Cunha Júnior, Joaquim José Alvim, André Luiz Oliveira, Cristóvão de Deus Martins Souza, Gregory Lauar de Carvalho, Handerson Dias Duarte Rocha, Rhayssa Fernanda Andrade Open Forum Infect Dis Poster Abstracts BACKGROUND: In December 2009, a cluster of patients with pneumonia was reported in the city of Wuhan, capital of Hubei province in China, caused by a novel coronavirus: SARS-CoV-2. The epidemiological compartmental susceptible-exposed-infected-recovered (SEIR) model has been previously used during the initial wave of the H1N1 influenza pandemic in 2009. This study investigates whether the SEIR model, associated to mobility changes parameters, can determine the likelihood of establishing control over an epidemic in a city, state or country. METHODS: The critical step in the prediction of COVID-19 by a SEIR model are the values of the basic reproduction number (R0) and the infectious period, in days. R0 and the infectious periods were calculated by mathematical constrained optimization, and used to determine the numerically minimum SEIR model errors in a country, based on COVID-19 data until april 11(th). The Community Mobility Reports from Google Maps (https://www.google.com/covid19/mobility/) provided mobility changes on april 5(th) compared to the baseline (Jan 3(th) to Feb 6(th)). The data was used to measure the non-pharmacological intervention adherence. The impact of each mobility component was made by logistic regression models. COVID-19 control was defined by R0 of the SEIR model in a country less than 1.0. Algorithm for the SEIR model applied to COVID-19 (initialization) [Image: see text] Table 01: Algorithm for the SEIR model applied to COVID-19 (calculation of new COVID-19 cases day-by-day) [Image: see text] RESULTS: Residential mobility restriction presented the higher logistic coefficient (17.7), meaning higher impact on outbreak control. Workplace mobility restriction was the second most effective measure, considering a restriction minimum of 56% for a 53% chance of outbreak control. Retail and recreation mobility presented 53%, and 86% respectively. Transit stations (96% and 54%) were also assessed. Park mobility restriction demonstrated the lowest effectiveness in outbreak control, considering that absolute (100%) restriction provided the lowest chance of outbreak control (46%). Table 2: The Community Mobility Reports from Google Maps: Mobility changes on April 5 compared to the baseline (5- week period; Jan 3–Feb 6, 2020): T_infectious and R0 obtained by using COVID-19 new cases day-by-day in each country, adjusted to the SEIR model by mathematical constrained optimization [Image: see text] Logistic regression models to evaluate the chance of an epidemic control based on the non-pharmacological interventions adherence [Image: see text] Simulation of the impact of the mobility component in the chance of outbreak control: analysis by using the logistic regression model summarized in Table 2 [Image: see text] CONCLUSION: Residential mobility restriction is the most effective measure. The degree to which mobility restrictions increase or decrease the overall epidemic size depends on the level of risk in each community and the characteristics of the disease. More research is required in order to estimate the optimal balance between mobility restriction, outbreak control, economy and freedom of movement. DISCLOSURES: All Authors: No reported disclosures Oxford University Press 2020-12-31 /pmc/articles/PMC7777597/ http://dx.doi.org/10.1093/ofid/ofaa439.672 Text en © The Author 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Poster Abstracts
Starling, Carlos Ernesto Ferreira
Marinho Couto, Bráulio Roberto Gonçalves
da Cunha Júnior, Joaquim José
Alvim, André Luiz
Oliveira, Cristóvão de Deus Martins
Souza, Gregory Lauar
de Carvalho, Handerson Dias Duarte
Rocha, Rhayssa Fernanda Andrade
479. Mobility Restrictions and COVID-19 Pandemic Outbreak Control
title 479. Mobility Restrictions and COVID-19 Pandemic Outbreak Control
title_full 479. Mobility Restrictions and COVID-19 Pandemic Outbreak Control
title_fullStr 479. Mobility Restrictions and COVID-19 Pandemic Outbreak Control
title_full_unstemmed 479. Mobility Restrictions and COVID-19 Pandemic Outbreak Control
title_short 479. Mobility Restrictions and COVID-19 Pandemic Outbreak Control
title_sort 479. mobility restrictions and covid-19 pandemic outbreak control
topic Poster Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777597/
http://dx.doi.org/10.1093/ofid/ofaa439.672
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