Cargando…
1283. New Generation Antiviral Conjugate (AVC): Stable, Safe, and Single
BACKGROUND: CD377 is a novel antiviral Fc-conjugate (AVC) development candidate for influenza prevention and treatment, comprising multiple copies of a novel potent small-molecule antiviral and the Fc domain of human IgG1. CD377 was designed as a stable, long-acting molecule for treatment and preven...
Autores principales: | Ong, Voon, Levin, James, Borchardt, Allen, Brady, Thomas P, Lam, Thanh, Noncovich, Alain, Fortier, Joanne, Amundson, Karin, Locke, Jeffrey B, Almaguer, Amanda, Dedeic, Nicholas, Hough, Grayson, Cole, Jason, Döhrmann, Simon, Grewal, Rajvir, Abelovski, Elizabeth, Balkovec, James M, Schlosser, Mike, Bartizal, Ken, Tari, Les |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777659/ http://dx.doi.org/10.1093/ofid/ofaa439.1466 |
Ejemplares similares
-
1276. Evaluation of CD377, a Novel Antiviral Fc-Conjugate (AVC), In Vitro Activity and In Vivo Efficacy in Immune-Competent and -Deficient (SCID) Lethal Mouse Models
por: Levin, James, et al.
Publicado: (2020) -
162. CD377, a Novel Antiviral Fc-conjugate, Demonstrates Potent Viral Burden Reduction Against Influenza a (H1N1) in Mouse and Ferret Models
por: Döhrmann, Simon, et al.
Publicado: (2020) -
2116. Efficacy of CD388, a Novel Drug Fc-Conjugate (DFC), is Driven by the Small Molecule Neuraminidase Inhibitor (NAI)
por: Döhrmann, Simon, et al.
Publicado: (2023) -
689. Therapeutic Efficacy of CB-012, a Novel Cloudbreak Antiviral Fc-Conjugate (AVC) in Lethal Mouse Models of Influenza A (H1N1) and Influenza B (Victoria)
por: Levin, James, et al.
Publicado: (2019) -
Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin
por: Ong, Voon, et al.
Publicado: (2016)