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1658. Particularities Of Pulmonary Tuberculosis Among Children
BACKGROUND: The diagnosis of pulmonary tuberculosis (PTB) among children remains challenging due to the non-specific clinical symptoms, laboratory features and the difficulty of sampling for microbiological investigations. We aimed to study clinical, therapeutic and evolutionary features of PTB amon...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777795/ http://dx.doi.org/10.1093/ofid/ofaa439.1836 |
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author | Hammami, Fatma Koubaa, Makram Chakroun, Amal Rekik, Khaoula Smaoui, Fatma Elleuch, Emna Marrakchi, Chakib Jemaa, Mounir Ben |
author_facet | Hammami, Fatma Koubaa, Makram Chakroun, Amal Rekik, Khaoula Smaoui, Fatma Elleuch, Emna Marrakchi, Chakib Jemaa, Mounir Ben |
author_sort | Hammami, Fatma |
collection | PubMed |
description | BACKGROUND: The diagnosis of pulmonary tuberculosis (PTB) among children remains challenging due to the non-specific clinical symptoms, laboratory features and the difficulty of sampling for microbiological investigations. We aimed to study clinical, therapeutic and evolutionary features of PTB among children. METHODS: We conducted a retrospective study including all children aged ≤ 18 years diagnosed with PTB between 1995 and 2016. RESULTS: We encountered 67 children with PTB, among whom 37 (55.2%) were female. The median age was 15 years [1-18years]. According to residency, 36 patients came from rural area (53.7%). We noted 7 cases (10.4%) of miliary tuberculosis (TB). Three cases of pleural TB (4.5%), one case of lymph node TB (1.5%) and one case of neuromeningeal TB were associated to PTB. Induced sputum or gastric aspirate were positive for Mycobacterium tuberculosis in 67.9% of the cases. Serologic tests for human immunodeficiency virus was positive in one case (1.5%). The mean duration of antitubercular therapy was 8 ±2 months. The treatment regimen was based on a quadritherapy for the first 2 months, followed by a bitherapy for the rest of the period. Fixed dose drug combinations were prescribed in 17 cases (25.3%). The disease evolution was favourable in 65 cases (97%). Two patients were dead (3%). There were no relapsing cases. CONCLUSION: Prompt diagnosis and treatment of PTB among children improve the prognosis. Screening for PTB among children exposed to adult tuberculosis is crucial in order to prevent the disease. DISCLOSURES: All Authors: No reported disclosures |
format | Online Article Text |
id | pubmed-7777795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77777952021-01-07 1658. Particularities Of Pulmonary Tuberculosis Among Children Hammami, Fatma Koubaa, Makram Chakroun, Amal Rekik, Khaoula Smaoui, Fatma Elleuch, Emna Marrakchi, Chakib Jemaa, Mounir Ben Open Forum Infect Dis Poster Abstracts BACKGROUND: The diagnosis of pulmonary tuberculosis (PTB) among children remains challenging due to the non-specific clinical symptoms, laboratory features and the difficulty of sampling for microbiological investigations. We aimed to study clinical, therapeutic and evolutionary features of PTB among children. METHODS: We conducted a retrospective study including all children aged ≤ 18 years diagnosed with PTB between 1995 and 2016. RESULTS: We encountered 67 children with PTB, among whom 37 (55.2%) were female. The median age was 15 years [1-18years]. According to residency, 36 patients came from rural area (53.7%). We noted 7 cases (10.4%) of miliary tuberculosis (TB). Three cases of pleural TB (4.5%), one case of lymph node TB (1.5%) and one case of neuromeningeal TB were associated to PTB. Induced sputum or gastric aspirate were positive for Mycobacterium tuberculosis in 67.9% of the cases. Serologic tests for human immunodeficiency virus was positive in one case (1.5%). The mean duration of antitubercular therapy was 8 ±2 months. The treatment regimen was based on a quadritherapy for the first 2 months, followed by a bitherapy for the rest of the period. Fixed dose drug combinations were prescribed in 17 cases (25.3%). The disease evolution was favourable in 65 cases (97%). Two patients were dead (3%). There were no relapsing cases. CONCLUSION: Prompt diagnosis and treatment of PTB among children improve the prognosis. Screening for PTB among children exposed to adult tuberculosis is crucial in order to prevent the disease. DISCLOSURES: All Authors: No reported disclosures Oxford University Press 2020-12-31 /pmc/articles/PMC7777795/ http://dx.doi.org/10.1093/ofid/ofaa439.1836 Text en © The Author 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Poster Abstracts Hammami, Fatma Koubaa, Makram Chakroun, Amal Rekik, Khaoula Smaoui, Fatma Elleuch, Emna Marrakchi, Chakib Jemaa, Mounir Ben 1658. Particularities Of Pulmonary Tuberculosis Among Children |
title | 1658. Particularities Of Pulmonary Tuberculosis Among Children |
title_full | 1658. Particularities Of Pulmonary Tuberculosis Among Children |
title_fullStr | 1658. Particularities Of Pulmonary Tuberculosis Among Children |
title_full_unstemmed | 1658. Particularities Of Pulmonary Tuberculosis Among Children |
title_short | 1658. Particularities Of Pulmonary Tuberculosis Among Children |
title_sort | 1658. particularities of pulmonary tuberculosis among children |
topic | Poster Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777795/ http://dx.doi.org/10.1093/ofid/ofaa439.1836 |
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