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68. Active Monitoring of a Healthcare Worker Cohort During the COVID-19 Epidemic

BACKGROUND: Initial CDC recommendations for passive monitoring of COVID-19 related symptoms among staff may not be sufficient in preventing the introduction and transmission of SARS-CoV-2 in healthcare settings. We therefore implemented active monitoring for SARS-CoV-2 infection in healthcare worker...

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Autores principales: Datta, Rupak, Campbell, Melissa, Wyllie, Anne, Casanovas-Massana, Arnau, Handoko, Ryan, Sewanan, Lorenzo, Naushad, Nida, Simonov, Michael, White, Elizabeth, Valdez, Jordan, Liu, Feimei, Omer, Saad, Cruz, Charles Dela, Farhadian, Shelli F, Ring, Aaron, Iwasaki, Akiko, Grubaugh, Nathan, Martinello, Richard A, Ko, Albert I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778054/
http://dx.doi.org/10.1093/ofid/ofaa439.378
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author Datta, Rupak
Campbell, Melissa
Wyllie, Anne
Casanovas-Massana, Arnau
Handoko, Ryan
Sewanan, Lorenzo
Naushad, Nida
Simonov, Michael
White, Elizabeth
Valdez, Jordan
Liu, Feimei
Omer, Saad
Cruz, Charles Dela
Farhadian, Shelli F
Ring, Aaron
Iwasaki, Akiko
Grubaugh, Nathan
Martinello, Richard A
Ko, Albert I
author_facet Datta, Rupak
Campbell, Melissa
Wyllie, Anne
Casanovas-Massana, Arnau
Handoko, Ryan
Sewanan, Lorenzo
Naushad, Nida
Simonov, Michael
White, Elizabeth
Valdez, Jordan
Liu, Feimei
Omer, Saad
Cruz, Charles Dela
Farhadian, Shelli F
Ring, Aaron
Iwasaki, Akiko
Grubaugh, Nathan
Martinello, Richard A
Ko, Albert I
author_sort Datta, Rupak
collection PubMed
description BACKGROUND: Initial CDC recommendations for passive monitoring of COVID-19 related symptoms among staff may not be sufficient in preventing the introduction and transmission of SARS-CoV-2 in healthcare settings. We therefore implemented active monitoring for SARS-CoV-2 infection in healthcare workers (HCWs) at an academic medical center during the COVID-19 epidemic in northeast US. METHODS: We recruited a cohort of HCWs at Yale New Haven Hospital who worked in COVID-19 units and did not have COVID-19 related symptoms between March 28 and June 1, 2020. During follow-up, participants provided daily information on symptoms by responding to a web-based questionnaire, self-administered nasopharyngeal (NP) and saliva specimens every 3 days, and blood specimens every 14 days. We performed SARS-CoV-2 RT-PCR and an anti-spike protein IgM and IgG ELISA to identify virological and serological-confirmed infection, respectively. RESULTS: We enrolled 525 (13%) amongst 4,136 HCW of whom daily information on symptoms and NP, saliva, and blood specimens were obtained for 66% (of 13208), 42% (or 1977), 44% (of 2071) and 65% (of 1099), respectively, of the follow-up measurement points. We identified 16 (3.0% of 525) HCWs with PCR-confirmed SARS-CoV-2 infection and an additional 12 (2.3% of 525) who were not tested by PCR or had negative PCR results but had serological evidence of infection. The overall cumulative incidence of SARS-CoV-2 infection was 5.3% (28 of 525) amongst HCWs. Cases were not identified by hospital protocols for passive staff self-monitoring for symptoms. Amongst 16 PCR-confirmed cases, 9 (56%) of the 16 PCR-confirmed HCW had symptoms during or after the date of initial detection. We did not identify an epidemiological link between the 28 confirmed cases. CONCLUSION: We found that a significant proportion (5.3%) of HCWs were infected with SARS-CoV-2 during the COVID-19 epidemic. In the setting of universal PPE use, infections were possibly acquired in the community rather than stemming from patient-HCW or HCW-HCW transmission. Passive monitoring of symptoms is inadequate in preventing introductions of SARS-CoV-2 into the healthcare setting due to asymptomatic and oligosymptomatic presentations. DISCLOSURES: All Authors: No reported disclosures
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spelling pubmed-77780542021-01-07 68. Active Monitoring of a Healthcare Worker Cohort During the COVID-19 Epidemic Datta, Rupak Campbell, Melissa Wyllie, Anne Casanovas-Massana, Arnau Handoko, Ryan Sewanan, Lorenzo Naushad, Nida Simonov, Michael White, Elizabeth Valdez, Jordan Liu, Feimei Omer, Saad Cruz, Charles Dela Farhadian, Shelli F Ring, Aaron Iwasaki, Akiko Grubaugh, Nathan Martinello, Richard A Ko, Albert I Open Forum Infect Dis Poster Abstracts BACKGROUND: Initial CDC recommendations for passive monitoring of COVID-19 related symptoms among staff may not be sufficient in preventing the introduction and transmission of SARS-CoV-2 in healthcare settings. We therefore implemented active monitoring for SARS-CoV-2 infection in healthcare workers (HCWs) at an academic medical center during the COVID-19 epidemic in northeast US. METHODS: We recruited a cohort of HCWs at Yale New Haven Hospital who worked in COVID-19 units and did not have COVID-19 related symptoms between March 28 and June 1, 2020. During follow-up, participants provided daily information on symptoms by responding to a web-based questionnaire, self-administered nasopharyngeal (NP) and saliva specimens every 3 days, and blood specimens every 14 days. We performed SARS-CoV-2 RT-PCR and an anti-spike protein IgM and IgG ELISA to identify virological and serological-confirmed infection, respectively. RESULTS: We enrolled 525 (13%) amongst 4,136 HCW of whom daily information on symptoms and NP, saliva, and blood specimens were obtained for 66% (of 13208), 42% (or 1977), 44% (of 2071) and 65% (of 1099), respectively, of the follow-up measurement points. We identified 16 (3.0% of 525) HCWs with PCR-confirmed SARS-CoV-2 infection and an additional 12 (2.3% of 525) who were not tested by PCR or had negative PCR results but had serological evidence of infection. The overall cumulative incidence of SARS-CoV-2 infection was 5.3% (28 of 525) amongst HCWs. Cases were not identified by hospital protocols for passive staff self-monitoring for symptoms. Amongst 16 PCR-confirmed cases, 9 (56%) of the 16 PCR-confirmed HCW had symptoms during or after the date of initial detection. We did not identify an epidemiological link between the 28 confirmed cases. CONCLUSION: We found that a significant proportion (5.3%) of HCWs were infected with SARS-CoV-2 during the COVID-19 epidemic. In the setting of universal PPE use, infections were possibly acquired in the community rather than stemming from patient-HCW or HCW-HCW transmission. Passive monitoring of symptoms is inadequate in preventing introductions of SARS-CoV-2 into the healthcare setting due to asymptomatic and oligosymptomatic presentations. DISCLOSURES: All Authors: No reported disclosures Oxford University Press 2020-12-31 /pmc/articles/PMC7778054/ http://dx.doi.org/10.1093/ofid/ofaa439.378 Text en © The Author 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Poster Abstracts
Datta, Rupak
Campbell, Melissa
Wyllie, Anne
Casanovas-Massana, Arnau
Handoko, Ryan
Sewanan, Lorenzo
Naushad, Nida
Simonov, Michael
White, Elizabeth
Valdez, Jordan
Liu, Feimei
Omer, Saad
Cruz, Charles Dela
Farhadian, Shelli F
Ring, Aaron
Iwasaki, Akiko
Grubaugh, Nathan
Martinello, Richard A
Ko, Albert I
68. Active Monitoring of a Healthcare Worker Cohort During the COVID-19 Epidemic
title 68. Active Monitoring of a Healthcare Worker Cohort During the COVID-19 Epidemic
title_full 68. Active Monitoring of a Healthcare Worker Cohort During the COVID-19 Epidemic
title_fullStr 68. Active Monitoring of a Healthcare Worker Cohort During the COVID-19 Epidemic
title_full_unstemmed 68. Active Monitoring of a Healthcare Worker Cohort During the COVID-19 Epidemic
title_short 68. Active Monitoring of a Healthcare Worker Cohort During the COVID-19 Epidemic
title_sort 68. active monitoring of a healthcare worker cohort during the covid-19 epidemic
topic Poster Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778054/
http://dx.doi.org/10.1093/ofid/ofaa439.378
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