Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice

The p53 tumor suppressor protein is a potent activator of proliferative arrest and cell death. In normal cells, this pathway is restrained by p53 protein degradation mediated by the E3-ubiquitin ligase activity of MDM2. Oncogenic stress releases p53 from MDM2 control, so activating the p53 response....

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Detalles Bibliográficos
Autores principales: Humpton, Timothy J., Nomura, Koji, Weber, Julia, Magnussen, Helge M., Hock, Andreas K., Nixon, Colin, Dhayade, Sandeep, Stevenson, David, Huang, Danny T., Strathdee, Douglas, Blyth, Karen, Vousden, Karen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778261/
https://www.ncbi.nlm.nih.gov/pubmed/33334825
http://dx.doi.org/10.1101/gad.341875.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778261/
https://www.ncbi.nlm.nih.gov/pubmed/33334825
http://dx.doi.org/10.1101/gad.341875.120

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