Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing

A case of multidrug-resistant tuberculosis is presented. It highlights the role of whole-genome sequencing, expanded phenotypic drug susceptibility testing, and enhanced case management, offering a more complete understanding of drug susceptibility to Mycobacterium tuberculosis. This approach guides...

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Detalles Bibliográficos
Autores principales: Dookie, Navisha, Padayatchi, Nesri, Lessells, Richard J, Naicker, Cherise L, Chotoo, Sunitha, Naidoo, Kogieleum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778351/
https://www.ncbi.nlm.nih.gov/pubmed/32384148
http://dx.doi.org/10.1093/cid/ciaa526
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author Dookie, Navisha
Padayatchi, Nesri
Lessells, Richard J
Naicker, Cherise L
Chotoo, Sunitha
Naidoo, Kogieleum
author_facet Dookie, Navisha
Padayatchi, Nesri
Lessells, Richard J
Naicker, Cherise L
Chotoo, Sunitha
Naidoo, Kogieleum
author_sort Dookie, Navisha
collection PubMed
description A case of multidrug-resistant tuberculosis is presented. It highlights the role of whole-genome sequencing, expanded phenotypic drug susceptibility testing, and enhanced case management, offering a more complete understanding of drug susceptibility to Mycobacterium tuberculosis. This approach guides an effective individualized treatment strategy that results in rapid sustained culture conversion.
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spelling pubmed-77783512021-01-07 Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing Dookie, Navisha Padayatchi, Nesri Lessells, Richard J Naicker, Cherise L Chotoo, Sunitha Naidoo, Kogieleum Clin Infect Dis Brief Reports A case of multidrug-resistant tuberculosis is presented. It highlights the role of whole-genome sequencing, expanded phenotypic drug susceptibility testing, and enhanced case management, offering a more complete understanding of drug susceptibility to Mycobacterium tuberculosis. This approach guides an effective individualized treatment strategy that results in rapid sustained culture conversion. Oxford University Press 2020-05-08 /pmc/articles/PMC7778351/ /pubmed/32384148 http://dx.doi.org/10.1093/cid/ciaa526 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Dookie, Navisha
Padayatchi, Nesri
Lessells, Richard J
Naicker, Cherise L
Chotoo, Sunitha
Naidoo, Kogieleum
Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing
title Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing
title_full Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing
title_fullStr Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing
title_full_unstemmed Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing
title_short Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing
title_sort individualized treatment of multidrug-resistant tuberculosis using whole-genome sequencing and expanded drug-susceptibility testing
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778351/
https://www.ncbi.nlm.nih.gov/pubmed/32384148
http://dx.doi.org/10.1093/cid/ciaa526
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