The oncogenic role of protein kinase D3 in cancer

Protein kinase D3 (PRKD3), a serine/threonine kinase, belongs to protein kinase D family, which contains three members: PRKD1, PRKD2, and PRKD3. PRKD3 is activated by many stimuli including phorbol esters, and G-protein-coupled receptor agonists. PRKD3 promotes cancer cell proliferation, growth, mig...

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Detalles Bibliográficos
Autores principales: Liu, Yan, Song, Hang, Zhou, Yehui, Ma, Xinxing, Xu, Jing, Yu, Zhenghong, Chen, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778554/
https://www.ncbi.nlm.nih.gov/pubmed/33403031
http://dx.doi.org/10.7150/jca.50899
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author Liu, Yan
Song, Hang
Zhou, Yehui
Ma, Xinxing
Xu, Jing
Yu, Zhenghong
Chen, Liming
author_facet Liu, Yan
Song, Hang
Zhou, Yehui
Ma, Xinxing
Xu, Jing
Yu, Zhenghong
Chen, Liming
author_sort Liu, Yan
collection PubMed
description Protein kinase D3 (PRKD3), a serine/threonine kinase, belongs to protein kinase D family, which contains three members: PRKD1, PRKD2, and PRKD3. PRKD3 is activated by many stimuli including phorbol esters, and G-protein-coupled receptor agonists. PRKD3 promotes cancer cell proliferation, growth, migration, and invasion in various tumor types including colorectal, gastric, hepatic, prostate, and breast cancer. Accumulating data supports that PRKD3 is a promising therapeutic target for treatment of cancer. This review discusses the functions and mechanisms of PRKD3 in promoting tumorigenesis and tumor progression of various tumor types as well as the latest developments of small-molecule inhibitors selection for PRKD/PRKD3.
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spelling pubmed-77785542021-01-04 The oncogenic role of protein kinase D3 in cancer Liu, Yan Song, Hang Zhou, Yehui Ma, Xinxing Xu, Jing Yu, Zhenghong Chen, Liming J Cancer Review Protein kinase D3 (PRKD3), a serine/threonine kinase, belongs to protein kinase D family, which contains three members: PRKD1, PRKD2, and PRKD3. PRKD3 is activated by many stimuli including phorbol esters, and G-protein-coupled receptor agonists. PRKD3 promotes cancer cell proliferation, growth, migration, and invasion in various tumor types including colorectal, gastric, hepatic, prostate, and breast cancer. Accumulating data supports that PRKD3 is a promising therapeutic target for treatment of cancer. This review discusses the functions and mechanisms of PRKD3 in promoting tumorigenesis and tumor progression of various tumor types as well as the latest developments of small-molecule inhibitors selection for PRKD/PRKD3. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7778554/ /pubmed/33403031 http://dx.doi.org/10.7150/jca.50899 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Liu, Yan
Song, Hang
Zhou, Yehui
Ma, Xinxing
Xu, Jing
Yu, Zhenghong
Chen, Liming
The oncogenic role of protein kinase D3 in cancer
title The oncogenic role of protein kinase D3 in cancer
title_full The oncogenic role of protein kinase D3 in cancer
title_fullStr The oncogenic role of protein kinase D3 in cancer
title_full_unstemmed The oncogenic role of protein kinase D3 in cancer
title_short The oncogenic role of protein kinase D3 in cancer
title_sort oncogenic role of protein kinase d3 in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778554/
https://www.ncbi.nlm.nih.gov/pubmed/33403031
http://dx.doi.org/10.7150/jca.50899
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