Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia

The Notch pathway is highly active in almost all patients with T-cell acute lymphoblastic leukemia (T-ALL), but the implication of Notch ligands in T-ALL remains underexplored. Methods: We used a genetic mouse model of Notch ligand delta like 4 (DLL4)-driven T-ALL and performed thymectomies and sple...

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Detalles Bibliográficos
Autores principales: Xiong, Huizhong, Mancini, Maicol, Gobert, Michael, Shen, Shiqian, Furtado, Glaucia C., Lira, Sergio A., Parkhurst, Christopher N., Garambois, Veronique, Brengues, Muriel, Tadokoro, Carlos E., Trimarchi, Thomas, Gómez-López, Gonzalo, Singh, Amartya, Khiabanian, Hossein, Minuzzo, Sonia, Indraccolo, Stefano, Lobry, Camille, Aifantis, Iannis, Herranz, Daniel, Lafaille, Juan J., Maraver, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778594/
https://www.ncbi.nlm.nih.gov/pubmed/33408769
http://dx.doi.org/10.7150/thno.48067

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