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Anti-allergic drug azelastine suppresses colon tumorigenesis by directly targeting ARF1 to inhibit IQGAP1-ERK-Drp1-mediated mitochondrial fission

This study aimed to screen novel anticancer strategies from FDA-approved non-cancer drugs and identify potential biomarkers and therapeutic targets for colorectal cancer (CRC). Methods: A library consisting of 1056 FDA-approved drugs was screened for anticancer agents. WST-1, colony-formation, flow...

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Detalles Bibliográficos
Autores principales:	Hu, Hui-Fang, Xu, Wen Wen, Li, Yang-Jia, He, Yan, Zhang, Wei-Xia, Liao, Long, Zhang, Qi-Hua, Han, Lei, Yin, Xing-Feng, Zhao, Xiao-Xu, Pan, Yun-Long, Li, Bin, He, Qing-Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778598/ https://www.ncbi.nlm.nih.gov/pubmed/33408784 http://dx.doi.org/10.7150/thno.48698

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