Development of the phenylpyrazolo[3,4-d]pyrimidine-based, insulin-like growth factor receptor/Src/AXL-targeting small molecule kinase inhibitor

Rationale: The type I insulin-like growth factor receptor (IGF-1R) signaling pathway plays key roles in the development and progression of numerous types of human cancers, and Src and AXL have been found to confer resistance to anti-IGF-1R therapies. Hence, co-targeting Src and AXL may be an effecti...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Ho Jin, Pham, Phuong Chi, Pei, Honglan, Lim, Bumhee, Hyun, Seung Yeob, Baek, Byungyeob, Kim, Byungjin, Kim, Yunha, Kim, Min-Hwan, Kang, Nae-Won, Min, Hye-Young, Kim, Dae-Duk, Lee, Jeeyeon, Lee, Ho-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778606/
https://www.ncbi.nlm.nih.gov/pubmed/33408789
http://dx.doi.org/10.7150/thno.48865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778606/
https://www.ncbi.nlm.nih.gov/pubmed/33408789
http://dx.doi.org/10.7150/thno.48865

Ejemplares similares