Cargando…
Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study
BACKGROUND: Evidence suggests that Oxidative stress has been shown to plays an important role in gestational diabetes mellitus (GDM) etiology. On the other hand, women with GDM are at an increased risk for complications such as endothelial dysfunction and cardiovascular diseases. OBJECTIVE: To inves...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Knowledge E
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778749/ https://www.ncbi.nlm.nih.gov/pubmed/33426413 http://dx.doi.org/10.18502/ijrm.v18i12.8024 |
_version_ | 1783631186377048064 |
---|---|
author | Aslfalah, Hadise Jamilian, Mehri Ansarihadipour, Hadi Abdollahi, Mahdi Khosrowbeygi, Ali |
author_facet | Aslfalah, Hadise Jamilian, Mehri Ansarihadipour, Hadi Abdollahi, Mahdi Khosrowbeygi, Ali |
author_sort | Aslfalah, Hadise |
collection | PubMed |
description | BACKGROUND: Evidence suggests that Oxidative stress has been shown to plays an important role in gestational diabetes mellitus (GDM) etiology. On the other hand, women with GDM are at an increased risk for complications such as endothelial dysfunction and cardiovascular diseases. OBJECTIVE: To investigate the effects of alpha-lipoic acid (ALA) on the maternal circulating values of lipid profile and lipid ratios in women with GDM. MATERIALS AND METHODS: Sixty women with GDM were participated in the present study. The ALA group (n = 30) received ALA (100 mg/day) and the placebo group (n = 30) received cellulose acetate (100 mg/day) for eight wk. The maternal circulating values of hemoglobin A1C, triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), non-HDL-C, and lipid ratios were assessed before and after the intervention. P-value [Formula: see text] 0.05 was considered as statistically significant. RESULTS: The values of TyG index (p [Formula: see text] 0.001), TG (p = 0.006), TG/HDL-C (p = 0.003), and AIP (p = 0.005) decreased significantly in the ALA group after the intervention. CONCLUSION: Maternal circulating values of TyG index, TG, TG/HDL, AIP decreased after eight wk of ALA supplementation in women with GDM. |
format | Online Article Text |
id | pubmed-7778749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Knowledge E |
record_format | MEDLINE/PubMed |
spelling | pubmed-77787492021-01-08 Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study Aslfalah, Hadise Jamilian, Mehri Ansarihadipour, Hadi Abdollahi, Mahdi Khosrowbeygi, Ali Int J Reprod Biomed Research Article BACKGROUND: Evidence suggests that Oxidative stress has been shown to plays an important role in gestational diabetes mellitus (GDM) etiology. On the other hand, women with GDM are at an increased risk for complications such as endothelial dysfunction and cardiovascular diseases. OBJECTIVE: To investigate the effects of alpha-lipoic acid (ALA) on the maternal circulating values of lipid profile and lipid ratios in women with GDM. MATERIALS AND METHODS: Sixty women with GDM were participated in the present study. The ALA group (n = 30) received ALA (100 mg/day) and the placebo group (n = 30) received cellulose acetate (100 mg/day) for eight wk. The maternal circulating values of hemoglobin A1C, triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), non-HDL-C, and lipid ratios were assessed before and after the intervention. P-value [Formula: see text] 0.05 was considered as statistically significant. RESULTS: The values of TyG index (p [Formula: see text] 0.001), TG (p = 0.006), TG/HDL-C (p = 0.003), and AIP (p = 0.005) decreased significantly in the ALA group after the intervention. CONCLUSION: Maternal circulating values of TyG index, TG, TG/HDL, AIP decreased after eight wk of ALA supplementation in women with GDM. Knowledge E 2020-12-21 /pmc/articles/PMC7778749/ /pubmed/33426413 http://dx.doi.org/10.18502/ijrm.v18i12.8024 Text en Copyright © 2020 Aslfalah et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Article Aslfalah, Hadise Jamilian, Mehri Ansarihadipour, Hadi Abdollahi, Mahdi Khosrowbeygi, Ali Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study |
title | Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study |
title_full | Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study |
title_fullStr | Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study |
title_full_unstemmed | Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study |
title_short | Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study |
title_sort | effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: a clinical trial study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778749/ https://www.ncbi.nlm.nih.gov/pubmed/33426413 http://dx.doi.org/10.18502/ijrm.v18i12.8024 |
work_keys_str_mv | AT aslfalahhadise effectofalphalipoicacidsupplementationonthelipidprofileandlipidratiosinwomenwithgestationaldiabetesmellitusaclinicaltrialstudy AT jamilianmehri effectofalphalipoicacidsupplementationonthelipidprofileandlipidratiosinwomenwithgestationaldiabetesmellitusaclinicaltrialstudy AT ansarihadipourhadi effectofalphalipoicacidsupplementationonthelipidprofileandlipidratiosinwomenwithgestationaldiabetesmellitusaclinicaltrialstudy AT abdollahimahdi effectofalphalipoicacidsupplementationonthelipidprofileandlipidratiosinwomenwithgestationaldiabetesmellitusaclinicaltrialstudy AT khosrowbeygiali effectofalphalipoicacidsupplementationonthelipidprofileandlipidratiosinwomenwithgestationaldiabetesmellitusaclinicaltrialstudy |