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Analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: A cross-sectional study

BACKGROUND: Poor ovarian reserve and a high rate of pregnancy failure associated with low quality and quantity of oocytes are observed in poor responders to in vitro fertilization. OBJECTIVE: To assess the effect of age, body mass index (BMI), endometriosis, and history of ovarian surgery on ovarian...

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Autores principales: Wiweko, Budi, Afdi, Quamila Fahrizani, Harzif, Achmad Kemal, Pratama, Gita, Sumapradja, Kanadi, Muharam, Raden, Hestiantoro, Andon, Zakirah, Sarah Chairani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Knowledge E 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778751/
https://www.ncbi.nlm.nih.gov/pubmed/33426417
http://dx.doi.org/10.18502/ijrm.v18i12.8028
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author Wiweko, Budi
Afdi, Quamila Fahrizani
Harzif, Achmad Kemal
Pratama, Gita
Sumapradja, Kanadi
Muharam, Raden
Hestiantoro, Andon
Zakirah, Sarah Chairani
author_facet Wiweko, Budi
Afdi, Quamila Fahrizani
Harzif, Achmad Kemal
Pratama, Gita
Sumapradja, Kanadi
Muharam, Raden
Hestiantoro, Andon
Zakirah, Sarah Chairani
author_sort Wiweko, Budi
collection PubMed
description BACKGROUND: Poor ovarian reserve and a high rate of pregnancy failure associated with low quality and quantity of oocytes are observed in poor responders to in vitro fertilization. OBJECTIVE: To assess the effect of age, body mass index (BMI), endometriosis, and history of ovarian surgery on ovarian reserve in a group of poor responders. MATERIALS AND METHODS: In this cross-sectional study 749 women who referred to Yasmin Clinic of Dr. Cipto Mangunkusumo National General Hospital from January 2013 to June 2017 were enrolled. Two definitions of poor responders and Poseidon criteria and consecutive sampling techniques were used. Participants were divided into good and poor responder groups based on the ovarian reserve test; participant with oocyte [Formula: see text] 3 was classified as a poor responder. Based on this, 188 participants with nine (4-47) oocytes were included in the poor responder group. While, good responder comprised of two (0-3) oocytes. RESULTS: Age and anti-Mullerian hormone level (AMH) were significantly associated with ovarian reserve in the poor-responder group (p [Formula: see text] 0.001). However, in multivariate analyses, age was the only significant predictor of ovarian response in the poor-responder group (p = 0.004). While endometriosis was the significant predictor of Poseidon groups 1 and 4, surgical history was the significant predictor of Poseidon groups 2 and 3. Meanwhile, an increase in BMI decreased the risk of classification under Poseidon group 3. CONCLUSION: Age, AMH, BMI, endometriosis, and history of ovarian surgery affected the risk of classification of the Poseidon group.
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spelling pubmed-77787512021-01-08 Analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: A cross-sectional study Wiweko, Budi Afdi, Quamila Fahrizani Harzif, Achmad Kemal Pratama, Gita Sumapradja, Kanadi Muharam, Raden Hestiantoro, Andon Zakirah, Sarah Chairani Int J Reprod Biomed Research Article BACKGROUND: Poor ovarian reserve and a high rate of pregnancy failure associated with low quality and quantity of oocytes are observed in poor responders to in vitro fertilization. OBJECTIVE: To assess the effect of age, body mass index (BMI), endometriosis, and history of ovarian surgery on ovarian reserve in a group of poor responders. MATERIALS AND METHODS: In this cross-sectional study 749 women who referred to Yasmin Clinic of Dr. Cipto Mangunkusumo National General Hospital from January 2013 to June 2017 were enrolled. Two definitions of poor responders and Poseidon criteria and consecutive sampling techniques were used. Participants were divided into good and poor responder groups based on the ovarian reserve test; participant with oocyte [Formula: see text] 3 was classified as a poor responder. Based on this, 188 participants with nine (4-47) oocytes were included in the poor responder group. While, good responder comprised of two (0-3) oocytes. RESULTS: Age and anti-Mullerian hormone level (AMH) were significantly associated with ovarian reserve in the poor-responder group (p [Formula: see text] 0.001). However, in multivariate analyses, age was the only significant predictor of ovarian response in the poor-responder group (p = 0.004). While endometriosis was the significant predictor of Poseidon groups 1 and 4, surgical history was the significant predictor of Poseidon groups 2 and 3. Meanwhile, an increase in BMI decreased the risk of classification under Poseidon group 3. CONCLUSION: Age, AMH, BMI, endometriosis, and history of ovarian surgery affected the risk of classification of the Poseidon group. Knowledge E 2020-12-21 /pmc/articles/PMC7778751/ /pubmed/33426417 http://dx.doi.org/10.18502/ijrm.v18i12.8028 Text en Copyright © 2020 Wiweko et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Article
Wiweko, Budi
Afdi, Quamila Fahrizani
Harzif, Achmad Kemal
Pratama, Gita
Sumapradja, Kanadi
Muharam, Raden
Hestiantoro, Andon
Zakirah, Sarah Chairani
Analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: A cross-sectional study
title Analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: A cross-sectional study
title_full Analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: A cross-sectional study
title_fullStr Analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: A cross-sectional study
title_full_unstemmed Analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: A cross-sectional study
title_short Analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: A cross-sectional study
title_sort analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778751/
https://www.ncbi.nlm.nih.gov/pubmed/33426417
http://dx.doi.org/10.18502/ijrm.v18i12.8028
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