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SMART: recent updates, new developments and status in 2020
SMART (Simple Modular Architecture Research Tool) is a web resource (https://smart.embl.de) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 9 contains manually curated models for more than 1300 protein domains, with a topical s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778883/ https://www.ncbi.nlm.nih.gov/pubmed/33104802 http://dx.doi.org/10.1093/nar/gkaa937 |
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author | Letunic, Ivica Khedkar, Supriya Bork, Peer |
author_facet | Letunic, Ivica Khedkar, Supriya Bork, Peer |
author_sort | Letunic, Ivica |
collection | PubMed |
description | SMART (Simple Modular Architecture Research Tool) is a web resource (https://smart.embl.de) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 9 contains manually curated models for more than 1300 protein domains, with a topical set of 68 new models added since our last update article (1). All the new models are for diverse recombinase families and subfamilies and as a set they provide a comprehensive overview of mobile element recombinases namely transposase, integrase, relaxase, resolvase, cas1 casposase and Xer like cellular recombinase. Further updates include the synchronization of the underlying protein databases with UniProt (2), Ensembl (3) and STRING (4), greatly increasing the total number of annotated domains and other protein features available in architecture analysis mode. Furthermore, SMART’s vector-based protein display engine has been extended and updated to use the latest web technologies and the domain architecture analysis components have been optimized to handle the increased number of protein features available. |
format | Online Article Text |
id | pubmed-7778883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77788832021-01-06 SMART: recent updates, new developments and status in 2020 Letunic, Ivica Khedkar, Supriya Bork, Peer Nucleic Acids Res Database Issue SMART (Simple Modular Architecture Research Tool) is a web resource (https://smart.embl.de) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 9 contains manually curated models for more than 1300 protein domains, with a topical set of 68 new models added since our last update article (1). All the new models are for diverse recombinase families and subfamilies and as a set they provide a comprehensive overview of mobile element recombinases namely transposase, integrase, relaxase, resolvase, cas1 casposase and Xer like cellular recombinase. Further updates include the synchronization of the underlying protein databases with UniProt (2), Ensembl (3) and STRING (4), greatly increasing the total number of annotated domains and other protein features available in architecture analysis mode. Furthermore, SMART’s vector-based protein display engine has been extended and updated to use the latest web technologies and the domain architecture analysis components have been optimized to handle the increased number of protein features available. Oxford University Press 2020-10-26 /pmc/articles/PMC7778883/ /pubmed/33104802 http://dx.doi.org/10.1093/nar/gkaa937 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Issue Letunic, Ivica Khedkar, Supriya Bork, Peer SMART: recent updates, new developments and status in 2020 |
title | SMART: recent updates, new developments and status in 2020 |
title_full | SMART: recent updates, new developments and status in 2020 |
title_fullStr | SMART: recent updates, new developments and status in 2020 |
title_full_unstemmed | SMART: recent updates, new developments and status in 2020 |
title_short | SMART: recent updates, new developments and status in 2020 |
title_sort | smart: recent updates, new developments and status in 2020 |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778883/ https://www.ncbi.nlm.nih.gov/pubmed/33104802 http://dx.doi.org/10.1093/nar/gkaa937 |
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