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MoonProt 3.0: an update of the moonlighting proteins database

MoonProt 3.0 (http://moonlightingproteins.org) is an updated open-access database storing expert-curated annotations for moonlighting proteins. Moonlighting proteins have two or more physiologically relevant distinct biochemical or biophysical functions performed by a single polypeptide chain. Here,...

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Autores principales: Chen, Chang, Liu, Haipeng, Zabad, Shadi, Rivera, Nina, Rowin, Emily, Hassan, Maheen, Gomez De Jesus, Stephanie M, Llinás Santos, Paola S, Kravchenko, Karyna, Mikhova, Mariia, Ketterer, Sophia, Shen, Annabel, Shen, Sophia, Navas, Erin, Horan, Bryan, Raudsepp, Jaak, Jeffery, Constance
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778978/
https://www.ncbi.nlm.nih.gov/pubmed/33245761
http://dx.doi.org/10.1093/nar/gkaa1101
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author Chen, Chang
Liu, Haipeng
Zabad, Shadi
Rivera, Nina
Rowin, Emily
Hassan, Maheen
Gomez De Jesus, Stephanie M
Llinás Santos, Paola S
Kravchenko, Karyna
Mikhova, Mariia
Ketterer, Sophia
Shen, Annabel
Shen, Sophia
Navas, Erin
Horan, Bryan
Raudsepp, Jaak
Jeffery, Constance
author_facet Chen, Chang
Liu, Haipeng
Zabad, Shadi
Rivera, Nina
Rowin, Emily
Hassan, Maheen
Gomez De Jesus, Stephanie M
Llinás Santos, Paola S
Kravchenko, Karyna
Mikhova, Mariia
Ketterer, Sophia
Shen, Annabel
Shen, Sophia
Navas, Erin
Horan, Bryan
Raudsepp, Jaak
Jeffery, Constance
author_sort Chen, Chang
collection PubMed
description MoonProt 3.0 (http://moonlightingproteins.org) is an updated open-access database storing expert-curated annotations for moonlighting proteins. Moonlighting proteins have two or more physiologically relevant distinct biochemical or biophysical functions performed by a single polypeptide chain. Here, we describe an expansion in the database since our previous report in the Database Issue of Nucleic Acids Research in 2018. For this release, the number of proteins annotated has been expanded to over 500 proteins and dozens of protein annotations have been updated with additional information, including more structures in the Protein Data Bank, compared with version 2.0. The new entries include more examples from humans, plants and archaea, more proteins involved in disease and proteins with different combinations of functions. More kinds of information about the proteins and the species in which they have multiple functions has been added, including CATH and SCOP classification of structure, known and predicted disorder, predicted transmembrane helices, type of organism, relationship of the protein to disease, and relationship of organism to cause of disease.
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spelling pubmed-77789782021-01-06 MoonProt 3.0: an update of the moonlighting proteins database Chen, Chang Liu, Haipeng Zabad, Shadi Rivera, Nina Rowin, Emily Hassan, Maheen Gomez De Jesus, Stephanie M Llinás Santos, Paola S Kravchenko, Karyna Mikhova, Mariia Ketterer, Sophia Shen, Annabel Shen, Sophia Navas, Erin Horan, Bryan Raudsepp, Jaak Jeffery, Constance Nucleic Acids Res Database Issue MoonProt 3.0 (http://moonlightingproteins.org) is an updated open-access database storing expert-curated annotations for moonlighting proteins. Moonlighting proteins have two or more physiologically relevant distinct biochemical or biophysical functions performed by a single polypeptide chain. Here, we describe an expansion in the database since our previous report in the Database Issue of Nucleic Acids Research in 2018. For this release, the number of proteins annotated has been expanded to over 500 proteins and dozens of protein annotations have been updated with additional information, including more structures in the Protein Data Bank, compared with version 2.0. The new entries include more examples from humans, plants and archaea, more proteins involved in disease and proteins with different combinations of functions. More kinds of information about the proteins and the species in which they have multiple functions has been added, including CATH and SCOP classification of structure, known and predicted disorder, predicted transmembrane helices, type of organism, relationship of the protein to disease, and relationship of organism to cause of disease. Oxford University Press 2020-11-27 /pmc/articles/PMC7778978/ /pubmed/33245761 http://dx.doi.org/10.1093/nar/gkaa1101 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Database Issue
Chen, Chang
Liu, Haipeng
Zabad, Shadi
Rivera, Nina
Rowin, Emily
Hassan, Maheen
Gomez De Jesus, Stephanie M
Llinás Santos, Paola S
Kravchenko, Karyna
Mikhova, Mariia
Ketterer, Sophia
Shen, Annabel
Shen, Sophia
Navas, Erin
Horan, Bryan
Raudsepp, Jaak
Jeffery, Constance
MoonProt 3.0: an update of the moonlighting proteins database
title MoonProt 3.0: an update of the moonlighting proteins database
title_full MoonProt 3.0: an update of the moonlighting proteins database
title_fullStr MoonProt 3.0: an update of the moonlighting proteins database
title_full_unstemmed MoonProt 3.0: an update of the moonlighting proteins database
title_short MoonProt 3.0: an update of the moonlighting proteins database
title_sort moonprot 3.0: an update of the moonlighting proteins database
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778978/
https://www.ncbi.nlm.nih.gov/pubmed/33245761
http://dx.doi.org/10.1093/nar/gkaa1101
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