Cargando…
RNAcentral 2021: secondary structure integration, improved sequence search and new member databases
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also includes secondary (2D) structure information for >13 million seq...
Formato: | Online Artículo Texto |
---|---|
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779037/ https://www.ncbi.nlm.nih.gov/pubmed/33106848 http://dx.doi.org/10.1093/nar/gkaa921 |
_version_ | 1783631250329698304 |
---|---|
collection | PubMed |
description | RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also includes secondary (2D) structure information for >13 million sequences, making RNAcentral the world’s largest RNA 2D structure database. The 2D diagrams are displayed using R2DT, a new 2D structure visualization method that uses consistent, reproducible and recognizable layouts for related RNAs. The sequence similarity search has been updated with a faster interface featuring facets for filtering search results by RNA type, organism, source database or any keyword. This sequence search tool is available as a reusable web component, and has been integrated into several RNAcentral member databases, including Rfam, miRBase and snoDB. To allow for a more fine-grained assignment of RNA types and subtypes, all RNAcentral sequences have been annotated with Sequence Ontology terms. The RNAcentral database continues to grow and provide a central data resource for the RNA community. RNAcentral is freely available at https://rnacentral.org. |
format | Online Article Text |
id | pubmed-7779037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77790372021-01-07 RNAcentral 2021: secondary structure integration, improved sequence search and new member databases Nucleic Acids Res Database Issue RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also includes secondary (2D) structure information for >13 million sequences, making RNAcentral the world’s largest RNA 2D structure database. The 2D diagrams are displayed using R2DT, a new 2D structure visualization method that uses consistent, reproducible and recognizable layouts for related RNAs. The sequence similarity search has been updated with a faster interface featuring facets for filtering search results by RNA type, organism, source database or any keyword. This sequence search tool is available as a reusable web component, and has been integrated into several RNAcentral member databases, including Rfam, miRBase and snoDB. To allow for a more fine-grained assignment of RNA types and subtypes, all RNAcentral sequences have been annotated with Sequence Ontology terms. The RNAcentral database continues to grow and provide a central data resource for the RNA community. RNAcentral is freely available at https://rnacentral.org. Oxford University Press 2020-10-27 /pmc/articles/PMC7779037/ /pubmed/33106848 http://dx.doi.org/10.1093/nar/gkaa921 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Issue RNAcentral 2021: secondary structure integration, improved sequence search and new member databases |
title | RNAcentral 2021: secondary structure integration, improved sequence search and new member databases |
title_full | RNAcentral 2021: secondary structure integration, improved sequence search and new member databases |
title_fullStr | RNAcentral 2021: secondary structure integration, improved sequence search and new member databases |
title_full_unstemmed | RNAcentral 2021: secondary structure integration, improved sequence search and new member databases |
title_short | RNAcentral 2021: secondary structure integration, improved sequence search and new member databases |
title_sort | rnacentral 2021: secondary structure integration, improved sequence search and new member databases |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779037/ https://www.ncbi.nlm.nih.gov/pubmed/33106848 http://dx.doi.org/10.1093/nar/gkaa921 |
work_keys_str_mv | AT rnacentral2021secondarystructureintegrationimprovedsequencesearchandnewmemberdatabases |