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MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation
Many studies have indicated that non-coding RNA (ncRNA) dysfunction is closely related to numerous diseases. Recently, accumulated ncRNA–disease associations have made related databases insufficient to meet the demands of biomedical research. The constant updating of ncRNA–disease resources has beco...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779040/ https://www.ncbi.nlm.nih.gov/pubmed/32833025 http://dx.doi.org/10.1093/nar/gkaa707 |
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author | Ning, Lin Cui, Tianyu Zheng, Boyang Wang, Nuo Luo, Jiaxin Yang, Beilei Du, Mengze Cheng, Jun Dou, Yiying Wang, Dong |
author_facet | Ning, Lin Cui, Tianyu Zheng, Boyang Wang, Nuo Luo, Jiaxin Yang, Beilei Du, Mengze Cheng, Jun Dou, Yiying Wang, Dong |
author_sort | Ning, Lin |
collection | PubMed |
description | Many studies have indicated that non-coding RNA (ncRNA) dysfunction is closely related to numerous diseases. Recently, accumulated ncRNA–disease associations have made related databases insufficient to meet the demands of biomedical research. The constant updating of ncRNA–disease resources has become essential. Here, we have updated the mammal ncRNA–disease repository (MNDR, http://www.rna-society.org/mndr/) to version 3.0, containing more than one million entries, four-fold increment in data compared to the previous version. Experimental and predicted circRNA–disease associations have been integrated, increasing the number of categories of ncRNAs to five, and the number of mammalian species to 11. Moreover, ncRNA–disease related drug annotations and associations, as well as ncRNA subcellular localizations and interactions, were added. In addition, three ncRNA–disease (miRNA/lncRNA/circRNA) prediction tools were provided, and the website was also optimized, making it more practical and user-friendly. In summary, MNDR v3.0 will be a valuable resource for the investigation of disease mechanisms and clinical treatment strategies. |
format | Online Article Text |
id | pubmed-7779040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77790402021-01-07 MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation Ning, Lin Cui, Tianyu Zheng, Boyang Wang, Nuo Luo, Jiaxin Yang, Beilei Du, Mengze Cheng, Jun Dou, Yiying Wang, Dong Nucleic Acids Res Database Issue Many studies have indicated that non-coding RNA (ncRNA) dysfunction is closely related to numerous diseases. Recently, accumulated ncRNA–disease associations have made related databases insufficient to meet the demands of biomedical research. The constant updating of ncRNA–disease resources has become essential. Here, we have updated the mammal ncRNA–disease repository (MNDR, http://www.rna-society.org/mndr/) to version 3.0, containing more than one million entries, four-fold increment in data compared to the previous version. Experimental and predicted circRNA–disease associations have been integrated, increasing the number of categories of ncRNAs to five, and the number of mammalian species to 11. Moreover, ncRNA–disease related drug annotations and associations, as well as ncRNA subcellular localizations and interactions, were added. In addition, three ncRNA–disease (miRNA/lncRNA/circRNA) prediction tools were provided, and the website was also optimized, making it more practical and user-friendly. In summary, MNDR v3.0 will be a valuable resource for the investigation of disease mechanisms and clinical treatment strategies. Oxford University Press 2020-08-24 /pmc/articles/PMC7779040/ /pubmed/32833025 http://dx.doi.org/10.1093/nar/gkaa707 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Database Issue Ning, Lin Cui, Tianyu Zheng, Boyang Wang, Nuo Luo, Jiaxin Yang, Beilei Du, Mengze Cheng, Jun Dou, Yiying Wang, Dong MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation |
title | MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation |
title_full | MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation |
title_fullStr | MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation |
title_full_unstemmed | MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation |
title_short | MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation |
title_sort | mndr v3.0: mammal ncrna–disease repository with increased coverage and annotation |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779040/ https://www.ncbi.nlm.nih.gov/pubmed/32833025 http://dx.doi.org/10.1093/nar/gkaa707 |
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