Cargando…
DrugCentral 2021 supports drug discovery and repositioning
DrugCentral is a public resource (http://drugcentral.org) that serves the scientific community by providing up-to-date drug information, as described in previous papers. The current release includes 109 newly approved (October 2018 through March 2020) active pharmaceutical ingredients in the US, Eur...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779058/ https://www.ncbi.nlm.nih.gov/pubmed/33151287 http://dx.doi.org/10.1093/nar/gkaa997 |
_version_ | 1783631255272685568 |
---|---|
author | Avram, Sorin Bologa, Cristian G Holmes, Jayme Bocci, Giovanni Wilson, Thomas B Nguyen, Dac-Trung Curpan, Ramona Halip, Liliana Bora, Alina Yang, Jeremy J Knockel, Jeffrey Sirimulla, Suman Ursu, Oleg Oprea, Tudor I |
author_facet | Avram, Sorin Bologa, Cristian G Holmes, Jayme Bocci, Giovanni Wilson, Thomas B Nguyen, Dac-Trung Curpan, Ramona Halip, Liliana Bora, Alina Yang, Jeremy J Knockel, Jeffrey Sirimulla, Suman Ursu, Oleg Oprea, Tudor I |
author_sort | Avram, Sorin |
collection | PubMed |
description | DrugCentral is a public resource (http://drugcentral.org) that serves the scientific community by providing up-to-date drug information, as described in previous papers. The current release includes 109 newly approved (October 2018 through March 2020) active pharmaceutical ingredients in the US, Europe, Japan and other countries; and two molecular entities (e.g. mefuparib) of interest for COVID19. New additions include a set of pharmacokinetic properties for ∼1000 drugs, and a sex-based separation of side effects, processed from FAERS (FDA Adverse Event Reporting System); as well as a drug repositioning prioritization scheme based on the market availability and intellectual property rights forFDA approved drugs. In the context of the COVID19 pandemic, we also incorporated REDIAL-2020, a machine learning platform that estimates anti-SARS-CoV-2 activities, as well as the ‘drugs in news’ feature offers a brief enumeration of the most interesting drugs at the present moment. The full database dump and data files are available for download from the DrugCentral web portal. |
format | Online Article Text |
id | pubmed-7779058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77790582021-01-07 DrugCentral 2021 supports drug discovery and repositioning Avram, Sorin Bologa, Cristian G Holmes, Jayme Bocci, Giovanni Wilson, Thomas B Nguyen, Dac-Trung Curpan, Ramona Halip, Liliana Bora, Alina Yang, Jeremy J Knockel, Jeffrey Sirimulla, Suman Ursu, Oleg Oprea, Tudor I Nucleic Acids Res Database Issue DrugCentral is a public resource (http://drugcentral.org) that serves the scientific community by providing up-to-date drug information, as described in previous papers. The current release includes 109 newly approved (October 2018 through March 2020) active pharmaceutical ingredients in the US, Europe, Japan and other countries; and two molecular entities (e.g. mefuparib) of interest for COVID19. New additions include a set of pharmacokinetic properties for ∼1000 drugs, and a sex-based separation of side effects, processed from FAERS (FDA Adverse Event Reporting System); as well as a drug repositioning prioritization scheme based on the market availability and intellectual property rights forFDA approved drugs. In the context of the COVID19 pandemic, we also incorporated REDIAL-2020, a machine learning platform that estimates anti-SARS-CoV-2 activities, as well as the ‘drugs in news’ feature offers a brief enumeration of the most interesting drugs at the present moment. The full database dump and data files are available for download from the DrugCentral web portal. Oxford University Press 2020-11-05 /pmc/articles/PMC7779058/ /pubmed/33151287 http://dx.doi.org/10.1093/nar/gkaa997 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Issue Avram, Sorin Bologa, Cristian G Holmes, Jayme Bocci, Giovanni Wilson, Thomas B Nguyen, Dac-Trung Curpan, Ramona Halip, Liliana Bora, Alina Yang, Jeremy J Knockel, Jeffrey Sirimulla, Suman Ursu, Oleg Oprea, Tudor I DrugCentral 2021 supports drug discovery and repositioning |
title | DrugCentral 2021 supports drug discovery and repositioning |
title_full | DrugCentral 2021 supports drug discovery and repositioning |
title_fullStr | DrugCentral 2021 supports drug discovery and repositioning |
title_full_unstemmed | DrugCentral 2021 supports drug discovery and repositioning |
title_short | DrugCentral 2021 supports drug discovery and repositioning |
title_sort | drugcentral 2021 supports drug discovery and repositioning |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779058/ https://www.ncbi.nlm.nih.gov/pubmed/33151287 http://dx.doi.org/10.1093/nar/gkaa997 |
work_keys_str_mv | AT avramsorin drugcentral2021supportsdrugdiscoveryandrepositioning AT bologacristiang drugcentral2021supportsdrugdiscoveryandrepositioning AT holmesjayme drugcentral2021supportsdrugdiscoveryandrepositioning AT boccigiovanni drugcentral2021supportsdrugdiscoveryandrepositioning AT wilsonthomasb drugcentral2021supportsdrugdiscoveryandrepositioning AT nguyendactrung drugcentral2021supportsdrugdiscoveryandrepositioning AT curpanramona drugcentral2021supportsdrugdiscoveryandrepositioning AT halipliliana drugcentral2021supportsdrugdiscoveryandrepositioning AT boraalina drugcentral2021supportsdrugdiscoveryandrepositioning AT yangjeremyj drugcentral2021supportsdrugdiscoveryandrepositioning AT knockeljeffrey drugcentral2021supportsdrugdiscoveryandrepositioning AT sirimullasuman drugcentral2021supportsdrugdiscoveryandrepositioning AT ursuoleg drugcentral2021supportsdrugdiscoveryandrepositioning AT opreatudori drugcentral2021supportsdrugdiscoveryandrepositioning |