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MASI: microbiota—active substance interactions database

Xenobiotic and host active substances interact with gut microbiota to influence human health and therapeutics. Dietary, pharmaceutical, herbal and environmental substances are modified by microbiota with altered bioavailabilities, bioactivities and toxic effects. Xenobiotics also affect microbiota w...

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Autores principales: Zeng, Xian, Yang, Xue, Fan, Jiajun, Tan, Ying, Ju, Lingyi, Shen, Wanxiang, Wang, Yali, Wang, Xinghao, Chen, Weiping, Ju, Dianwen, Chen, Yu Zong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779062/
https://www.ncbi.nlm.nih.gov/pubmed/33125077
http://dx.doi.org/10.1093/nar/gkaa924
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author Zeng, Xian
Yang, Xue
Fan, Jiajun
Tan, Ying
Ju, Lingyi
Shen, Wanxiang
Wang, Yali
Wang, Xinghao
Chen, Weiping
Ju, Dianwen
Chen, Yu Zong
author_facet Zeng, Xian
Yang, Xue
Fan, Jiajun
Tan, Ying
Ju, Lingyi
Shen, Wanxiang
Wang, Yali
Wang, Xinghao
Chen, Weiping
Ju, Dianwen
Chen, Yu Zong
author_sort Zeng, Xian
collection PubMed
description Xenobiotic and host active substances interact with gut microbiota to influence human health and therapeutics. Dietary, pharmaceutical, herbal and environmental substances are modified by microbiota with altered bioavailabilities, bioactivities and toxic effects. Xenobiotics also affect microbiota with health implications. Knowledge of these microbiota and active substance interactions is important for understanding microbiota-regulated functions and therapeutics. Established microbiota databases provide useful information about the microbiota-disease associations, diet and drug interventions, and microbiota modulation of drugs. However, there is insufficient information on the active substances modified by microbiota and the abundance of gut bacteria in humans. Only ∼7% drugs are covered by the established databases. To complement these databases, we developed MASI, Microbiota—Active Substance Interactions database, for providing the information about the microbiota alteration of various substances, substance alteration of microbiota, and the abundance of gut bacteria in humans. These include 1,051 pharmaceutical, 103 dietary, 119 herbal, 46 probiotic, 142 environmental substances interacting with 806 microbiota species linked to 56 diseases and 784 microbiota–disease associations. MASI covers 11 215 bacteria-pharmaceutical, 914 bacteria-herbal, 309 bacteria-dietary, 753 bacteria-environmental substance interactions and the abundance profiles of 259 bacteria species in 3465 patients and 5334 healthy individuals. MASI is freely accessible at http://www.aiddlab.com/MASI.
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spelling pubmed-77790622021-01-07 MASI: microbiota—active substance interactions database Zeng, Xian Yang, Xue Fan, Jiajun Tan, Ying Ju, Lingyi Shen, Wanxiang Wang, Yali Wang, Xinghao Chen, Weiping Ju, Dianwen Chen, Yu Zong Nucleic Acids Res Database Issue Xenobiotic and host active substances interact with gut microbiota to influence human health and therapeutics. Dietary, pharmaceutical, herbal and environmental substances are modified by microbiota with altered bioavailabilities, bioactivities and toxic effects. Xenobiotics also affect microbiota with health implications. Knowledge of these microbiota and active substance interactions is important for understanding microbiota-regulated functions and therapeutics. Established microbiota databases provide useful information about the microbiota-disease associations, diet and drug interventions, and microbiota modulation of drugs. However, there is insufficient information on the active substances modified by microbiota and the abundance of gut bacteria in humans. Only ∼7% drugs are covered by the established databases. To complement these databases, we developed MASI, Microbiota—Active Substance Interactions database, for providing the information about the microbiota alteration of various substances, substance alteration of microbiota, and the abundance of gut bacteria in humans. These include 1,051 pharmaceutical, 103 dietary, 119 herbal, 46 probiotic, 142 environmental substances interacting with 806 microbiota species linked to 56 diseases and 784 microbiota–disease associations. MASI covers 11 215 bacteria-pharmaceutical, 914 bacteria-herbal, 309 bacteria-dietary, 753 bacteria-environmental substance interactions and the abundance profiles of 259 bacteria species in 3465 patients and 5334 healthy individuals. MASI is freely accessible at http://www.aiddlab.com/MASI. Oxford University Press 2020-10-30 /pmc/articles/PMC7779062/ /pubmed/33125077 http://dx.doi.org/10.1093/nar/gkaa924 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Database Issue
Zeng, Xian
Yang, Xue
Fan, Jiajun
Tan, Ying
Ju, Lingyi
Shen, Wanxiang
Wang, Yali
Wang, Xinghao
Chen, Weiping
Ju, Dianwen
Chen, Yu Zong
MASI: microbiota—active substance interactions database
title MASI: microbiota—active substance interactions database
title_full MASI: microbiota—active substance interactions database
title_fullStr MASI: microbiota—active substance interactions database
title_full_unstemmed MASI: microbiota—active substance interactions database
title_short MASI: microbiota—active substance interactions database
title_sort masi: microbiota—active substance interactions database
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779062/
https://www.ncbi.nlm.nih.gov/pubmed/33125077
http://dx.doi.org/10.1093/nar/gkaa924
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