The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes

Microorganisms produce natural products that are frequently used in the development of antibacterial, antiviral, and anticancer drugs, pesticides, herbicides, or fungicides. In recent years, genome mining has evolved into a prominent method to access this potential. antiSMASH is one of the most popu...

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Detalles Bibliográficos
Autores principales: Blin, Kai, Shaw, Simon, Kautsar, Satria A, Medema, Marnix H, Weber, Tilmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Database Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779067/
https://www.ncbi.nlm.nih.gov/pubmed/33152079
http://dx.doi.org/10.1093/nar/gkaa978
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author Blin, Kai
Shaw, Simon
Kautsar, Satria A
Medema, Marnix H
Weber, Tilmann
author_facet Blin, Kai
Shaw, Simon
Kautsar, Satria A
Medema, Marnix H
Weber, Tilmann
author_sort Blin, Kai
collection PubMed
description Microorganisms produce natural products that are frequently used in the development of antibacterial, antiviral, and anticancer drugs, pesticides, herbicides, or fungicides. In recent years, genome mining has evolved into a prominent method to access this potential. antiSMASH is one of the most popular tools for this task. Here, we present version 3 of the antiSMASH database, providing a means to access and query precomputed antiSMASH-5.2-detected biosynthetic gene clusters from representative, publicly available, high-quality microbial genomes via an interactive graphical user interface. In version 3, the database contains 147 517 high quality BGC regions from 388 archaeal, 25 236 bacterial and 177 fungal genomes and is available at https://antismash-db.secondarymetabolites.org/.
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spelling pubmed-77790672021-01-07 The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes Blin, Kai Shaw, Simon Kautsar, Satria A Medema, Marnix H Weber, Tilmann Nucleic Acids Res Database Issue Microorganisms produce natural products that are frequently used in the development of antibacterial, antiviral, and anticancer drugs, pesticides, herbicides, or fungicides. In recent years, genome mining has evolved into a prominent method to access this potential. antiSMASH is one of the most popular tools for this task. Here, we present version 3 of the antiSMASH database, providing a means to access and query precomputed antiSMASH-5.2-detected biosynthetic gene clusters from representative, publicly available, high-quality microbial genomes via an interactive graphical user interface. In version 3, the database contains 147 517 high quality BGC regions from 388 archaeal, 25 236 bacterial and 177 fungal genomes and is available at https://antismash-db.secondarymetabolites.org/. Oxford University Press 2020-11-05 /pmc/articles/PMC7779067/ /pubmed/33152079 http://dx.doi.org/10.1093/nar/gkaa978 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Issue
Blin, Kai
Shaw, Simon
Kautsar, Satria A
Medema, Marnix H
Weber, Tilmann
The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes
title The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes
title_full The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes
title_fullStr The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes
title_full_unstemmed The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes
title_short The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes
title_sort antismash database version 3: increased taxonomic coverage and new query features for modular enzymes
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779067/
https://www.ncbi.nlm.nih.gov/pubmed/33152079
http://dx.doi.org/10.1093/nar/gkaa978
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