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Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19

The newly identified 2019 novel coronavirus (SARS-CoV-2) has become a public health concern globally posing a significant threat to human health and economy and creating an unprecedented crisis in all spheres of the global life. Emergence of new genotypes of SARS-CoV during the last few years has po...

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Autores principales: Bhattacharjee, Arghyadeep, Saha, Manish, Halder, Arpita, Debnath, Arka, Mukherjee, Oindrilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779084/
https://www.ncbi.nlm.nih.gov/pubmed/33392670
http://dx.doi.org/10.1007/s00284-020-02310-x
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author Bhattacharjee, Arghyadeep
Saha, Manish
Halder, Arpita
Debnath, Arka
Mukherjee, Oindrilla
author_facet Bhattacharjee, Arghyadeep
Saha, Manish
Halder, Arpita
Debnath, Arka
Mukherjee, Oindrilla
author_sort Bhattacharjee, Arghyadeep
collection PubMed
description The newly identified 2019 novel coronavirus (SARS-CoV-2) has become a public health concern globally posing a significant threat to human health and economy and creating an unprecedented crisis in all spheres of the global life. Emergence of new genotypes of SARS-CoV during the last few years has pointed out the limited efficacy of available vaccines and antivirals, constraining the global response to the COVID-19 outburst to largely monitoring/containment. There is high priority for treatment regimes and new potential therapeutic and vaccine strategies. Several candidates have shown promising outcomes in various in vitro and in vivo models. In addition, clinical trials are in progress to test conceivable therapies showing promising outcomes in various in vivo studies. Unfortunately, very little information is available in the scientific scope which offers details to the diverse strategies being targeted to fight the pandemic, particularly with respect to the molecular targets. This review article summarizes and highlights the ongoing advances and approaches that are being carried out across the globe in designing vaccines and novel therapeutics, with particular reference to the previous knowledge gained from other viral infections like with the earlier SARS and MERS-CoV. A detailed knowledge may pave the way to combat this pandemic COVID-19 as well as prevent similar deadly epidemics in future.
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spelling pubmed-77790842021-01-04 Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19 Bhattacharjee, Arghyadeep Saha, Manish Halder, Arpita Debnath, Arka Mukherjee, Oindrilla Curr Microbiol Review Article The newly identified 2019 novel coronavirus (SARS-CoV-2) has become a public health concern globally posing a significant threat to human health and economy and creating an unprecedented crisis in all spheres of the global life. Emergence of new genotypes of SARS-CoV during the last few years has pointed out the limited efficacy of available vaccines and antivirals, constraining the global response to the COVID-19 outburst to largely monitoring/containment. There is high priority for treatment regimes and new potential therapeutic and vaccine strategies. Several candidates have shown promising outcomes in various in vitro and in vivo models. In addition, clinical trials are in progress to test conceivable therapies showing promising outcomes in various in vivo studies. Unfortunately, very little information is available in the scientific scope which offers details to the diverse strategies being targeted to fight the pandemic, particularly with respect to the molecular targets. This review article summarizes and highlights the ongoing advances and approaches that are being carried out across the globe in designing vaccines and novel therapeutics, with particular reference to the previous knowledge gained from other viral infections like with the earlier SARS and MERS-CoV. A detailed knowledge may pave the way to combat this pandemic COVID-19 as well as prevent similar deadly epidemics in future. Springer US 2021-01-03 2021 /pmc/articles/PMC7779084/ /pubmed/33392670 http://dx.doi.org/10.1007/s00284-020-02310-x Text en © Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Bhattacharjee, Arghyadeep
Saha, Manish
Halder, Arpita
Debnath, Arka
Mukherjee, Oindrilla
Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19
title Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19
title_full Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19
title_fullStr Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19
title_full_unstemmed Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19
title_short Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19
title_sort therapeutics and vaccines: strengthening our fight against the global pandemic covid-19
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779084/
https://www.ncbi.nlm.nih.gov/pubmed/33392670
http://dx.doi.org/10.1007/s00284-020-02310-x
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