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Low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study
AIMS/INTRODUCTION: Dyslipidemia plays a critical role in the pathogenesis of metabolic syndrome and diabetes. Evidence has increasingly shown that the ratio of low‐ to high‐density lipoprotein cholesterol (LDL‐C/HDL‐C) is a novel marker for increased risk of insulin resistance and cardiovascular dis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779276/ https://www.ncbi.nlm.nih.gov/pubmed/32506632 http://dx.doi.org/10.1111/jdi.13316 |
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author | Wei, Limin Wei, Meng Chen, Lei Liang, Shanshan Gao, Fanfan Cheng, Xin Jiang, Hongli |
author_facet | Wei, Limin Wei, Meng Chen, Lei Liang, Shanshan Gao, Fanfan Cheng, Xin Jiang, Hongli |
author_sort | Wei, Limin |
collection | PubMed |
description | AIMS/INTRODUCTION: Dyslipidemia plays a critical role in the pathogenesis of metabolic syndrome and diabetes. Evidence has increasingly shown that the ratio of low‐ to high‐density lipoprotein cholesterol (LDL‐C/HDL‐C) is a novel marker for increased risk of insulin resistance and cardiovascular diseases. However, the correlation between the LDL‐C/HDL‐C ratio and diabetes risk is rarely reported. This is the first study to investigate the association between the LDL‐C/HDL‐C ratio and new‐onset diabetes in a large community‐based cohort. MATERIALS AND METHODS: In this retrospective cohort study, a total of 116,661 adults without baseline diabetes were enrolled. Participants were stratified into four groups based on LDL‐C/HDL‐C ratio quartiles. The outcome of interest was new‐onset diabetes. RESULTS: During a median follow‐up period of 2.98 years, 2,681 (2.3%) new diabetes cases were recorded. The total cumulative incidence of diabetes progressively increased alongside LDL‐C/HDL‐C ratio quartiles (0.31, 0.43, 0.68 and 0.88%, respectively, P‐value for trend <0.001). After adjusting for potential confounders, using the lowest quartile of the LDL‐C/HDL‐C ratio as the reference, the risk of diabetes increased with LDL‐C/HDL‐C ratio quartiles (P‐value for trend <0.001); in particular, from the second to fourth quartile, hazard ratios were 1.18 (95% confidence interval 0.87–1.59), 1.42 (95% confidence interval 1.07–1.90) and 1.92 (95% confidence interval 1.43–2.59), respectively. The results were also robust to challenges in multiple sensitivity analyses. CONCLUSIONS: Among the Chinese population, elevated LDL‐C/HDL‐C ratio might be an independent risk factor for new‐onset diabetes. |
format | Online Article Text |
id | pubmed-7779276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77792762021-01-08 Low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study Wei, Limin Wei, Meng Chen, Lei Liang, Shanshan Gao, Fanfan Cheng, Xin Jiang, Hongli J Diabetes Investig Articles AIMS/INTRODUCTION: Dyslipidemia plays a critical role in the pathogenesis of metabolic syndrome and diabetes. Evidence has increasingly shown that the ratio of low‐ to high‐density lipoprotein cholesterol (LDL‐C/HDL‐C) is a novel marker for increased risk of insulin resistance and cardiovascular diseases. However, the correlation between the LDL‐C/HDL‐C ratio and diabetes risk is rarely reported. This is the first study to investigate the association between the LDL‐C/HDL‐C ratio and new‐onset diabetes in a large community‐based cohort. MATERIALS AND METHODS: In this retrospective cohort study, a total of 116,661 adults without baseline diabetes were enrolled. Participants were stratified into four groups based on LDL‐C/HDL‐C ratio quartiles. The outcome of interest was new‐onset diabetes. RESULTS: During a median follow‐up period of 2.98 years, 2,681 (2.3%) new diabetes cases were recorded. The total cumulative incidence of diabetes progressively increased alongside LDL‐C/HDL‐C ratio quartiles (0.31, 0.43, 0.68 and 0.88%, respectively, P‐value for trend <0.001). After adjusting for potential confounders, using the lowest quartile of the LDL‐C/HDL‐C ratio as the reference, the risk of diabetes increased with LDL‐C/HDL‐C ratio quartiles (P‐value for trend <0.001); in particular, from the second to fourth quartile, hazard ratios were 1.18 (95% confidence interval 0.87–1.59), 1.42 (95% confidence interval 1.07–1.90) and 1.92 (95% confidence interval 1.43–2.59), respectively. The results were also robust to challenges in multiple sensitivity analyses. CONCLUSIONS: Among the Chinese population, elevated LDL‐C/HDL‐C ratio might be an independent risk factor for new‐onset diabetes. John Wiley and Sons Inc. 2020-07-07 2021-01 /pmc/articles/PMC7779276/ /pubmed/32506632 http://dx.doi.org/10.1111/jdi.13316 Text en © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Wei, Limin Wei, Meng Chen, Lei Liang, Shanshan Gao, Fanfan Cheng, Xin Jiang, Hongli Low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study |
title | Low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study |
title_full | Low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study |
title_fullStr | Low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study |
title_full_unstemmed | Low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study |
title_short | Low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study |
title_sort | low‐density lipoprotein cholesterol : high‐density lipoprotein cholesterol ratio is associated with incident diabetes in chinese adults: a retrospective cohort study |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779276/ https://www.ncbi.nlm.nih.gov/pubmed/32506632 http://dx.doi.org/10.1111/jdi.13316 |
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