β-Catenin/Lin28/let-7 regulatory network determines type II alveolar epithelial stem cell differentiation phenotypes following thoracic irradiation

The contribution of type II alveolar epithelial stem cells (AEC II) to radiation-induced lung fibrosis (RILF) is largely unknown. Cell differentiation phenotypes are determined by the balance between Lin28 and lethal-7 microRNA (let-7 miRNA). Lin28 is activated by β-catenin. The aim of this study wa...

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Detalles Bibliográficos
Autores principales: Liu, Xiaozhuan, Zhang, Tingting, Zhou, Jianwei, Xiao, Ziting, Li, Yanjun, Zhang, Yuwei, Yue, Haodi, Li, Zhitao, Tian, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Oncology/Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779353/
https://www.ncbi.nlm.nih.gov/pubmed/33302295
http://dx.doi.org/10.1093/jrr/rraa119

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