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A dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trials for cervical cancer

The postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trial is a phase II study to evaluate toxicity following hypofractionated intensity modulated radiation therapy (IMRT) for cervical cancer. This study describes the results of a benchmark procedure for RT quality ass...

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Autores principales: Cho, Won Kyung, Kim, Heejung, Park, Won, Kim, Sang-Won, Kim, Jongwon, Lee, Kang Kyu, Oh, Jeong Geun, Yoon, Mee Sun, Song, Ju-Young, Ahn, Ki Jung, Park, Sung Kwang, Choi, Jin Hwa, Bak, Jino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779361/
https://www.ncbi.nlm.nih.gov/pubmed/33392616
http://dx.doi.org/10.1093/jrr/rraa085
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author Cho, Won Kyung
Kim, Heejung
Park, Won
Kim, Sang-Won
Kim, Jongwon
Lee, Kang Kyu
Oh, Jeong Geun
Yoon, Mee Sun
Song, Ju-Young
Ahn, Ki Jung
Park, Sung Kwang
Choi, Jin Hwa
Bak, Jino
author_facet Cho, Won Kyung
Kim, Heejung
Park, Won
Kim, Sang-Won
Kim, Jongwon
Lee, Kang Kyu
Oh, Jeong Geun
Yoon, Mee Sun
Song, Ju-Young
Ahn, Ki Jung
Park, Sung Kwang
Choi, Jin Hwa
Bak, Jino
author_sort Cho, Won Kyung
collection PubMed
description The postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trial is a phase II study to evaluate toxicity following hypofractionated intensity modulated radiation therapy (IMRT) for cervical cancer. This study describes the results of a benchmark procedure for RT quality assurance of the POHIM-RT trial. Six participating institutions were provided computed tomography for RT planning and an IMRT plan for a sample and were instructed to delineate volumes, create a treatment plan and quality assurance (QA) plan, and submit the results of all procedures. The inter-institutional agreements on RT volume and plan results were evaluated using the kappa value and dice similarity coefficients. The simultaneous truth and performance level estimation (STAPLE) method was employed to generate a consensus target volume. The treatment volumes, organs-at-risk volumes, and results of the RT plan and QA reported by the institutions were acceptable and adhered well to the protocol. In terms of clinical target volume (CTV) delineation, there were differences between the institutions, particularly in vaginal cuff and paracolpium subsites. Consensus CTV was generated from the collected CTVs with the STAPLE method. The participating institutions showed considerable agreement regarding volume, dose and QA results. To improve CTV agreement in CTV, we provided feedback with images of the consensus target volume and detailed written guidelines for specific subsites that were the most heterogeneous.
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spelling pubmed-77793612021-01-07 A dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trials for cervical cancer Cho, Won Kyung Kim, Heejung Park, Won Kim, Sang-Won Kim, Jongwon Lee, Kang Kyu Oh, Jeong Geun Yoon, Mee Sun Song, Ju-Young Ahn, Ki Jung Park, Sung Kwang Choi, Jin Hwa Bak, Jino J Radiat Res Oncology/Medicine The postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trial is a phase II study to evaluate toxicity following hypofractionated intensity modulated radiation therapy (IMRT) for cervical cancer. This study describes the results of a benchmark procedure for RT quality assurance of the POHIM-RT trial. Six participating institutions were provided computed tomography for RT planning and an IMRT plan for a sample and were instructed to delineate volumes, create a treatment plan and quality assurance (QA) plan, and submit the results of all procedures. The inter-institutional agreements on RT volume and plan results were evaluated using the kappa value and dice similarity coefficients. The simultaneous truth and performance level estimation (STAPLE) method was employed to generate a consensus target volume. The treatment volumes, organs-at-risk volumes, and results of the RT plan and QA reported by the institutions were acceptable and adhered well to the protocol. In terms of clinical target volume (CTV) delineation, there were differences between the institutions, particularly in vaginal cuff and paracolpium subsites. Consensus CTV was generated from the collected CTVs with the STAPLE method. The participating institutions showed considerable agreement regarding volume, dose and QA results. To improve CTV agreement in CTV, we provided feedback with images of the consensus target volume and detailed written guidelines for specific subsites that were the most heterogeneous. Oxford University Press 2020-10-14 /pmc/articles/PMC7779361/ /pubmed/33392616 http://dx.doi.org/10.1093/jrr/rraa085 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Oncology/Medicine
Cho, Won Kyung
Kim, Heejung
Park, Won
Kim, Sang-Won
Kim, Jongwon
Lee, Kang Kyu
Oh, Jeong Geun
Yoon, Mee Sun
Song, Ju-Young
Ahn, Ki Jung
Park, Sung Kwang
Choi, Jin Hwa
Bak, Jino
A dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trials for cervical cancer
title A dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trials for cervical cancer
title_full A dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trials for cervical cancer
title_fullStr A dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trials for cervical cancer
title_full_unstemmed A dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trials for cervical cancer
title_short A dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (POHIM-RT) trials for cervical cancer
title_sort dummy-run evaluation of postoperative hypofractionated intensity-modulated radiation therapy (pohim-rt) trials for cervical cancer
topic Oncology/Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779361/
https://www.ncbi.nlm.nih.gov/pubmed/33392616
http://dx.doi.org/10.1093/jrr/rraa085
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