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Ki67 and P53 Expression in Relation to Clinicopathological Features in Phyllodes Tumour of the Breast

OBJECTIVE: Phyllodes tumour (PT) is a rare fibroepithelial neoplasm of the breast that carries a risk of malignancy. Histopathological examination remains a gold standard for diagnosis. The usage of the immunohistochemical markers of Ki67 and p53 acts as a supplement method, particularly for the mal...

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Autores principales: Ali, Nurul Atiah Mohd, Nasaruddin, Ahmad Fazlin, Mohamed, Syarah Syamimi, Rahman, Wan Faiziah Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779430/
https://www.ncbi.nlm.nih.gov/pubmed/32986365
http://dx.doi.org/10.31557/APJCP.2020.21.9.2653
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author Ali, Nurul Atiah Mohd
Nasaruddin, Ahmad Fazlin
Mohamed, Syarah Syamimi
Rahman, Wan Faiziah Wan
author_facet Ali, Nurul Atiah Mohd
Nasaruddin, Ahmad Fazlin
Mohamed, Syarah Syamimi
Rahman, Wan Faiziah Wan
author_sort Ali, Nurul Atiah Mohd
collection PubMed
description OBJECTIVE: Phyllodes tumour (PT) is a rare fibroepithelial neoplasm of the breast that carries a risk of malignancy. Histopathological examination remains a gold standard for diagnosis. The usage of the immunohistochemical markers of Ki67 and p53 acts as a supplement method, particularly for the malignant PT. We aim here to study the expression of these markers in PT and to see their relation to the tumour grading. METHODOLOGY: We conducted a retrospective cross-sectional study on 57 archived formalin-fixed paraffin-embedded tissue blocks of PT from the years 2015 to 2018 from two hospitals in East Coast Malaysia. The histopathological examination and immunohistochemical stain for Ki67 and p53 were analysed. RESULTS: There was an association between clinical descriptive data of skin changes, lump size of more than 3 cm, cytological atypia, stromal hypercellularity, mitosis and immunohistochemistry with the clinical diagnosis of PT. Both marked expression of Ki67 and p53 were seen in borderline and malignant PT. Our study showed that in the presence of high mitotic figures, marked expression of Ki67 was only seen in cases of malignant PT. CONCLUSION: We found a significant association of Ki67 and p53 expressions, high mitosis and other descriptive histopathological features in malignant PT. Further study with larger sample size is recommended to predict tumour grade and prognosis as well as the disease-free survival of the tumour.
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spelling pubmed-77794302021-01-08 Ki67 and P53 Expression in Relation to Clinicopathological Features in Phyllodes Tumour of the Breast Ali, Nurul Atiah Mohd Nasaruddin, Ahmad Fazlin Mohamed, Syarah Syamimi Rahman, Wan Faiziah Wan Asian Pac J Cancer Prev Research Article OBJECTIVE: Phyllodes tumour (PT) is a rare fibroepithelial neoplasm of the breast that carries a risk of malignancy. Histopathological examination remains a gold standard for diagnosis. The usage of the immunohistochemical markers of Ki67 and p53 acts as a supplement method, particularly for the malignant PT. We aim here to study the expression of these markers in PT and to see their relation to the tumour grading. METHODOLOGY: We conducted a retrospective cross-sectional study on 57 archived formalin-fixed paraffin-embedded tissue blocks of PT from the years 2015 to 2018 from two hospitals in East Coast Malaysia. The histopathological examination and immunohistochemical stain for Ki67 and p53 were analysed. RESULTS: There was an association between clinical descriptive data of skin changes, lump size of more than 3 cm, cytological atypia, stromal hypercellularity, mitosis and immunohistochemistry with the clinical diagnosis of PT. Both marked expression of Ki67 and p53 were seen in borderline and malignant PT. Our study showed that in the presence of high mitotic figures, marked expression of Ki67 was only seen in cases of malignant PT. CONCLUSION: We found a significant association of Ki67 and p53 expressions, high mitosis and other descriptive histopathological features in malignant PT. Further study with larger sample size is recommended to predict tumour grade and prognosis as well as the disease-free survival of the tumour. West Asia Organization for Cancer Prevention 2020-09 /pmc/articles/PMC7779430/ /pubmed/32986365 http://dx.doi.org/10.31557/APJCP.2020.21.9.2653 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ali, Nurul Atiah Mohd
Nasaruddin, Ahmad Fazlin
Mohamed, Syarah Syamimi
Rahman, Wan Faiziah Wan
Ki67 and P53 Expression in Relation to Clinicopathological Features in Phyllodes Tumour of the Breast
title Ki67 and P53 Expression in Relation to Clinicopathological Features in Phyllodes Tumour of the Breast
title_full Ki67 and P53 Expression in Relation to Clinicopathological Features in Phyllodes Tumour of the Breast
title_fullStr Ki67 and P53 Expression in Relation to Clinicopathological Features in Phyllodes Tumour of the Breast
title_full_unstemmed Ki67 and P53 Expression in Relation to Clinicopathological Features in Phyllodes Tumour of the Breast
title_short Ki67 and P53 Expression in Relation to Clinicopathological Features in Phyllodes Tumour of the Breast
title_sort ki67 and p53 expression in relation to clinicopathological features in phyllodes tumour of the breast
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779430/
https://www.ncbi.nlm.nih.gov/pubmed/32986365
http://dx.doi.org/10.31557/APJCP.2020.21.9.2653
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