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Phenomenon of music-induced opening of the blood-brain barrier in healthy mice

Music plays a more important role in our life than just being an entertainment. For example, it can be used as an anti-anxiety therapy of human and animals. However, the unsafe listening of loud music triggers hearing loss in millions of young people and professional musicians (rock, jazz and sympho...

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Autores principales: Semyachkina-Glushkovskaya, O., Esmat, A., Bragin, D., Bragina, O., Shirokov, A. A., Navolokin, N., Yang, Y., Abdurashitov, A., Khorovodov, A., Terskov, A., Klimova, M., Mamedova, A., Fedosov, I., Tuchin, V., Kurths, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779516/
https://www.ncbi.nlm.nih.gov/pubmed/33323086
http://dx.doi.org/10.1098/rspb.2020.2337
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author Semyachkina-Glushkovskaya, O.
Esmat, A.
Bragin, D.
Bragina, O.
Shirokov, A. A.
Navolokin, N.
Yang, Y.
Abdurashitov, A.
Khorovodov, A.
Terskov, A.
Klimova, M.
Mamedova, A.
Fedosov, I.
Tuchin, V.
Kurths, J.
author_facet Semyachkina-Glushkovskaya, O.
Esmat, A.
Bragin, D.
Bragina, O.
Shirokov, A. A.
Navolokin, N.
Yang, Y.
Abdurashitov, A.
Khorovodov, A.
Terskov, A.
Klimova, M.
Mamedova, A.
Fedosov, I.
Tuchin, V.
Kurths, J.
author_sort Semyachkina-Glushkovskaya, O.
collection PubMed
description Music plays a more important role in our life than just being an entertainment. For example, it can be used as an anti-anxiety therapy of human and animals. However, the unsafe listening of loud music triggers hearing loss in millions of young people and professional musicians (rock, jazz and symphony orchestra) owing to exposure to damaging sound levels using personal audio devices or at noisy entertainment venues including nightclubs, discotheques, bars and concerts. Therefore, it is important to understand how loud music affects us. In this pioneering study on healthy mice, we discover that loud rock music below the safety threshold causes opening of the blood-brain barrier (OBBB), which plays a vital role in protecting the brain from viruses, bacteria and toxins. We clearly demonstrate that listening to loud music during 2 h in an intermittent adaptive regime is accompanied by delayed (1 h after music exposure) and short-lasting to (during 1–4 h) OBBB to low and high molecular weight compounds without cochlear and brain impairments. We present the systemic and molecular mechanisms responsible for music-induced OBBB. Finally, a revision of our traditional knowledge about the BBB nature and the novel strategies in optimizing of sound-mediated methods for brain drug delivery are discussed.
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spelling pubmed-77795162021-01-05 Phenomenon of music-induced opening of the blood-brain barrier in healthy mice Semyachkina-Glushkovskaya, O. Esmat, A. Bragin, D. Bragina, O. Shirokov, A. A. Navolokin, N. Yang, Y. Abdurashitov, A. Khorovodov, A. Terskov, A. Klimova, M. Mamedova, A. Fedosov, I. Tuchin, V. Kurths, J. Proc Biol Sci Neuroscience and Cognition Music plays a more important role in our life than just being an entertainment. For example, it can be used as an anti-anxiety therapy of human and animals. However, the unsafe listening of loud music triggers hearing loss in millions of young people and professional musicians (rock, jazz and symphony orchestra) owing to exposure to damaging sound levels using personal audio devices or at noisy entertainment venues including nightclubs, discotheques, bars and concerts. Therefore, it is important to understand how loud music affects us. In this pioneering study on healthy mice, we discover that loud rock music below the safety threshold causes opening of the blood-brain barrier (OBBB), which plays a vital role in protecting the brain from viruses, bacteria and toxins. We clearly demonstrate that listening to loud music during 2 h in an intermittent adaptive regime is accompanied by delayed (1 h after music exposure) and short-lasting to (during 1–4 h) OBBB to low and high molecular weight compounds without cochlear and brain impairments. We present the systemic and molecular mechanisms responsible for music-induced OBBB. Finally, a revision of our traditional knowledge about the BBB nature and the novel strategies in optimizing of sound-mediated methods for brain drug delivery are discussed. The Royal Society 2020-12-23 2020-12-16 /pmc/articles/PMC7779516/ /pubmed/33323086 http://dx.doi.org/10.1098/rspb.2020.2337 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Neuroscience and Cognition
Semyachkina-Glushkovskaya, O.
Esmat, A.
Bragin, D.
Bragina, O.
Shirokov, A. A.
Navolokin, N.
Yang, Y.
Abdurashitov, A.
Khorovodov, A.
Terskov, A.
Klimova, M.
Mamedova, A.
Fedosov, I.
Tuchin, V.
Kurths, J.
Phenomenon of music-induced opening of the blood-brain barrier in healthy mice
title Phenomenon of music-induced opening of the blood-brain barrier in healthy mice
title_full Phenomenon of music-induced opening of the blood-brain barrier in healthy mice
title_fullStr Phenomenon of music-induced opening of the blood-brain barrier in healthy mice
title_full_unstemmed Phenomenon of music-induced opening of the blood-brain barrier in healthy mice
title_short Phenomenon of music-induced opening of the blood-brain barrier in healthy mice
title_sort phenomenon of music-induced opening of the blood-brain barrier in healthy mice
topic Neuroscience and Cognition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779516/
https://www.ncbi.nlm.nih.gov/pubmed/33323086
http://dx.doi.org/10.1098/rspb.2020.2337
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