Cargando…
Phenomenon of music-induced opening of the blood-brain barrier in healthy mice
Music plays a more important role in our life than just being an entertainment. For example, it can be used as an anti-anxiety therapy of human and animals. However, the unsafe listening of loud music triggers hearing loss in millions of young people and professional musicians (rock, jazz and sympho...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779516/ https://www.ncbi.nlm.nih.gov/pubmed/33323086 http://dx.doi.org/10.1098/rspb.2020.2337 |
_version_ | 1783631348125138944 |
---|---|
author | Semyachkina-Glushkovskaya, O. Esmat, A. Bragin, D. Bragina, O. Shirokov, A. A. Navolokin, N. Yang, Y. Abdurashitov, A. Khorovodov, A. Terskov, A. Klimova, M. Mamedova, A. Fedosov, I. Tuchin, V. Kurths, J. |
author_facet | Semyachkina-Glushkovskaya, O. Esmat, A. Bragin, D. Bragina, O. Shirokov, A. A. Navolokin, N. Yang, Y. Abdurashitov, A. Khorovodov, A. Terskov, A. Klimova, M. Mamedova, A. Fedosov, I. Tuchin, V. Kurths, J. |
author_sort | Semyachkina-Glushkovskaya, O. |
collection | PubMed |
description | Music plays a more important role in our life than just being an entertainment. For example, it can be used as an anti-anxiety therapy of human and animals. However, the unsafe listening of loud music triggers hearing loss in millions of young people and professional musicians (rock, jazz and symphony orchestra) owing to exposure to damaging sound levels using personal audio devices or at noisy entertainment venues including nightclubs, discotheques, bars and concerts. Therefore, it is important to understand how loud music affects us. In this pioneering study on healthy mice, we discover that loud rock music below the safety threshold causes opening of the blood-brain barrier (OBBB), which plays a vital role in protecting the brain from viruses, bacteria and toxins. We clearly demonstrate that listening to loud music during 2 h in an intermittent adaptive regime is accompanied by delayed (1 h after music exposure) and short-lasting to (during 1–4 h) OBBB to low and high molecular weight compounds without cochlear and brain impairments. We present the systemic and molecular mechanisms responsible for music-induced OBBB. Finally, a revision of our traditional knowledge about the BBB nature and the novel strategies in optimizing of sound-mediated methods for brain drug delivery are discussed. |
format | Online Article Text |
id | pubmed-7779516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-77795162021-01-05 Phenomenon of music-induced opening of the blood-brain barrier in healthy mice Semyachkina-Glushkovskaya, O. Esmat, A. Bragin, D. Bragina, O. Shirokov, A. A. Navolokin, N. Yang, Y. Abdurashitov, A. Khorovodov, A. Terskov, A. Klimova, M. Mamedova, A. Fedosov, I. Tuchin, V. Kurths, J. Proc Biol Sci Neuroscience and Cognition Music plays a more important role in our life than just being an entertainment. For example, it can be used as an anti-anxiety therapy of human and animals. However, the unsafe listening of loud music triggers hearing loss in millions of young people and professional musicians (rock, jazz and symphony orchestra) owing to exposure to damaging sound levels using personal audio devices or at noisy entertainment venues including nightclubs, discotheques, bars and concerts. Therefore, it is important to understand how loud music affects us. In this pioneering study on healthy mice, we discover that loud rock music below the safety threshold causes opening of the blood-brain barrier (OBBB), which plays a vital role in protecting the brain from viruses, bacteria and toxins. We clearly demonstrate that listening to loud music during 2 h in an intermittent adaptive regime is accompanied by delayed (1 h after music exposure) and short-lasting to (during 1–4 h) OBBB to low and high molecular weight compounds without cochlear and brain impairments. We present the systemic and molecular mechanisms responsible for music-induced OBBB. Finally, a revision of our traditional knowledge about the BBB nature and the novel strategies in optimizing of sound-mediated methods for brain drug delivery are discussed. The Royal Society 2020-12-23 2020-12-16 /pmc/articles/PMC7779516/ /pubmed/33323086 http://dx.doi.org/10.1098/rspb.2020.2337 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Neuroscience and Cognition Semyachkina-Glushkovskaya, O. Esmat, A. Bragin, D. Bragina, O. Shirokov, A. A. Navolokin, N. Yang, Y. Abdurashitov, A. Khorovodov, A. Terskov, A. Klimova, M. Mamedova, A. Fedosov, I. Tuchin, V. Kurths, J. Phenomenon of music-induced opening of the blood-brain barrier in healthy mice |
title | Phenomenon of music-induced opening of the blood-brain barrier in healthy mice |
title_full | Phenomenon of music-induced opening of the blood-brain barrier in healthy mice |
title_fullStr | Phenomenon of music-induced opening of the blood-brain barrier in healthy mice |
title_full_unstemmed | Phenomenon of music-induced opening of the blood-brain barrier in healthy mice |
title_short | Phenomenon of music-induced opening of the blood-brain barrier in healthy mice |
title_sort | phenomenon of music-induced opening of the blood-brain barrier in healthy mice |
topic | Neuroscience and Cognition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779516/ https://www.ncbi.nlm.nih.gov/pubmed/33323086 http://dx.doi.org/10.1098/rspb.2020.2337 |
work_keys_str_mv | AT semyachkinaglushkovskayao phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT esmata phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT bragind phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT braginao phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT shirokovaa phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT navolokinn phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT yangy phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT abdurashitova phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT khorovodova phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT terskova phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT klimovam phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT mamedovaa phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT fedosovi phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT tuchinv phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice AT kurthsj phenomenonofmusicinducedopeningofthebloodbrainbarrierinhealthymice |