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Obesity and Bone Health: A Complex Link

So far, the connections between obesity and skeleton have been extensively explored, but the results are inconsistent. Obesity is thought to affect bone health through a variety of mechanisms, including body weight, fat volume, bone formation/resorption, proinflammatory cytokines together with bone...

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Autores principales: Hou, Jing, He, Chen, He, Wenzhen, Yang, Mi, Luo, Xianghang, Li, Changjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779553/
https://www.ncbi.nlm.nih.gov/pubmed/33409277
http://dx.doi.org/10.3389/fcell.2020.600181
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author Hou, Jing
He, Chen
He, Wenzhen
Yang, Mi
Luo, Xianghang
Li, Changjun
author_facet Hou, Jing
He, Chen
He, Wenzhen
Yang, Mi
Luo, Xianghang
Li, Changjun
author_sort Hou, Jing
collection PubMed
description So far, the connections between obesity and skeleton have been extensively explored, but the results are inconsistent. Obesity is thought to affect bone health through a variety of mechanisms, including body weight, fat volume, bone formation/resorption, proinflammatory cytokines together with bone marrow microenvironment. In this review, we will mainly describe the effects of adipokines secreted by white adipose tissue on bone cells, as well as the interaction between brown adipose tissue, bone marrow adipose tissue, and bone metabolism. Meanwhile, this review also reviews the evidence for the effects of adipose tissue and its distribution on bone mass and bone-related diseases, along with the correlation between different populations with obesity and bone health. And we describe changes in bone metabolism in patients with anorexia nervosa or type 2 diabetes. In summary, all of these findings show that the response of skeleton to obesity is complex and depends on diversified factors, such as mechanical loading, obesity type, the location of adipose tissue, gender, age, bone sites, and secreted cytokines, and that these factors may exert a primary function in bone health.
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spelling pubmed-77795532021-01-05 Obesity and Bone Health: A Complex Link Hou, Jing He, Chen He, Wenzhen Yang, Mi Luo, Xianghang Li, Changjun Front Cell Dev Biol Cell and Developmental Biology So far, the connections between obesity and skeleton have been extensively explored, but the results are inconsistent. Obesity is thought to affect bone health through a variety of mechanisms, including body weight, fat volume, bone formation/resorption, proinflammatory cytokines together with bone marrow microenvironment. In this review, we will mainly describe the effects of adipokines secreted by white adipose tissue on bone cells, as well as the interaction between brown adipose tissue, bone marrow adipose tissue, and bone metabolism. Meanwhile, this review also reviews the evidence for the effects of adipose tissue and its distribution on bone mass and bone-related diseases, along with the correlation between different populations with obesity and bone health. And we describe changes in bone metabolism in patients with anorexia nervosa or type 2 diabetes. In summary, all of these findings show that the response of skeleton to obesity is complex and depends on diversified factors, such as mechanical loading, obesity type, the location of adipose tissue, gender, age, bone sites, and secreted cytokines, and that these factors may exert a primary function in bone health. Frontiers Media S.A. 2020-12-21 /pmc/articles/PMC7779553/ /pubmed/33409277 http://dx.doi.org/10.3389/fcell.2020.600181 Text en Copyright © 2020 Hou, He, He, Yang, Luo and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Hou, Jing
He, Chen
He, Wenzhen
Yang, Mi
Luo, Xianghang
Li, Changjun
Obesity and Bone Health: A Complex Link
title Obesity and Bone Health: A Complex Link
title_full Obesity and Bone Health: A Complex Link
title_fullStr Obesity and Bone Health: A Complex Link
title_full_unstemmed Obesity and Bone Health: A Complex Link
title_short Obesity and Bone Health: A Complex Link
title_sort obesity and bone health: a complex link
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779553/
https://www.ncbi.nlm.nih.gov/pubmed/33409277
http://dx.doi.org/10.3389/fcell.2020.600181
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