Targeting MicroRNA-125b Promotes Neurite Outgrowth but Represses Cell Apoptosis and Inflammation via Blocking PTGS2 and CDK5 in a FOXQ1-Dependent Way in Alzheimer Disease

This study aimed to explore the molecular regulatory network among microRNA-125b (miR-125b), forkhead box Q1 (FOXQ1), prostaglandin-endoperoxide synthase 2 (PTGS2), and cyclin-dependent kinase 5 (CDK5), as well as their effects on cell apoptosis, neurite outgrowth, and inflammation in Alzheimer dise...

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Detalles Bibliográficos
Autores principales: Zhuang, Jingcong, Chen, Zhongjie, Cai, Pingping, Wang, Rong, Yang, Qingwei, Li, Longling, Yang, Huili, Zhu, Renjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779636/
https://www.ncbi.nlm.nih.gov/pubmed/33408612
http://dx.doi.org/10.3389/fncel.2020.587747

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