Cargando…

Synthetic strategies for pyrrolo[2,1-f][1,2,4]triazine: the parent moiety of antiviral drug remdesivir

[Image: see text] This review summarizes diverse synthetic protocols for the preparation of pyrrolo[2,1-f][1,2,4]triazine derivatives, covering literature sources from the past two decades. For effective representation, the synthetic methods toward the title compound are classified into six distinct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rai, Gaurav S., Maru, Jayesh J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779642/ https://www.ncbi.nlm.nih.gov/pubmed/33424029 http://dx.doi.org/10.1007/s10593-020-02844-9

Ejemplares similares

Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir
por: Roy, Sarabindu, et al.
Publicado: (2022)

Regio- and Diastereoselective 1,3-Dipolar Cycloadditions of 1,2,4-Triazin-1-ium Ylides: a Straightforward Synthetic Route to Polysubstituted Pyrrolo[2,1-f][1,2,4]triazines
por: Galeta, Juraj, et al.
Publicado: (2022)

Pyrrolo[2,1-f][1,2,4]triazine: a promising fused heterocycle to target kinases in cancer therapy
por: Singh, Sarbjit, et al.
Publicado: (2021)

Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain
por: Dzierba, Carolyn D., et al.
Publicado: (2023)

Novel chalcone derivatives containing a 1,2,4-triazine moiety: design, synthesis, antibacterial and antiviral activities
por: Tang, Xu, et al.
Publicado: (2019)

Synthesis of pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones: Rearrangement of pyrrolo[1,2-d][1,3,4]oxadiazines and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles
por: Son, Kkonnip, et al.
Publicado: (2016)

Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity
por: Santra, Sougata, et al.
Publicado: (2023)

Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity
por: Saad, Hosam A., et al.
Publicado: (2011)

Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-c][1,2,4]triazolo[3,4-f][1,2,4]triazines
por: El Azab, Islam H., et al.
Publicado: (2020)

Strain-Promoted Reaction of 1,2,4-Triazines with Bicyclononynes
por: Horner, Katherine A, et al.
Publicado: (2015)

Nucleophile-induced ring contraction in pyrrolo[2,1-c][1,4]benzothiazines: access to pyrrolo[2,1-b][1,3]benzothiazoles
por: Lystsova, Ekaterina A, et al.
Publicado: (2023)

5,6-Dimethyl-1,2,4-triazin-3-amine
por: Wu, Man-Hua, et al.
Publicado: (2011)

3-Methylsulfanyl-5-phenyl-1,2,4-triazine
por: Hamri, Salha, et al.
Publicado: (2014)

Efficient Routes to Pyrazolo[3,4-e][1,2,4]triazines and a New Ring System: [1,2,4]Triazino[5,6-d][1,2,3]triazines
por: Al-Matar, Hamad Mohamed, et al.
Publicado: (2010)

Design, synthesis, cytotoxicity evaluation and docking studies of 1,2,4-triazine derivatives bearing different arylidene-hydrazinyl moieties as potential mTOR inhibitors
por: Ranjbar, Sara, et al.
Publicado: (2018)

2-(5,6-Diphenyl-1,2,4-triazin-3-yl)aniline
por: Mojzych, Mariusz, et al.
Publicado: (2012)

The discovery of pyridinium 1,2,4-triazines with enhanced performance in bioconjugation reactions
por: Siegl, Sebastian J., et al.
Publicado: (2017)

Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer
por: Hermanowicz, Justyna Magdalena, et al.
Publicado: (2021)

Tris(3-amino-5,6-dimethyl-1,2,4-triazine-κN (2))silver(I) trifluromethanesulfonate–3-amino-5,6-dimethyl-1,2,4-triazine (1/1)
por: Jiang, Yu-Hang, et al.
Publicado: (2011)

4-Hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-c][1,2,4]triazines: synthesis, antiviral activity, and electrochemical characteristics
por: Drokin, R. A., et al.
Publicado: (2022)

Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives
por: Popovici, Lacramioara, et al.
Publicado: (2019)

Synthesis and In Vitro Evaluation of 8-Pyridinyl-Substituted Benzo[e]imidazo[2,1-c][1,2,4]triazines as Phosphodiesterase 2A Inhibitors
por: Ritawidya, Rien, et al.
Publicado: (2019)

Revisiting the Synthesis of Functionally Substituted 1,4-Dihydrobenzo[e][1,2,4]triazines
por: Epishina, Margarita A., et al.
Publicado: (2022)

3-Amino-5,6-dimethyl-1,2,4-triazin-2-ium nitrate
por: Bel Haj Salah, Souhir, et al.
Publicado: (2013)

5,6-Diphenyl-3-(3-pyridyl)-1,2,4-triazine
por: Jian, Fang-Fang, et al.
Publicado: (2010)

First Synthesis of 3-Glycopyranosyl-1,2,4-Triazines and Some Cycloadditions Thereof
por: Bokor, Éva, et al.
Publicado: (2022)

Pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dithione
por: Ourahou, Sarah, et al.
Publicado: (2010)

Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols
por: Drokin, Roman A., et al.
Publicado: (2021)

2,3-Dihydropyrrolo[2,1-b]quinazoline-9(1H)-thione
por: Nasrullayev, Azizbek O., et al.
Publicado: (2012)

Corrosion Mitigation Performance of N80 Steel in 5% Sulfamic Acid Medium by Applying Novel Tetrahydro-1,2,4-triazines Including Triazene Moieties: Electrochemical and Theoretical Approaches
por: Abd El-Lateef, Hany M., et al.
Publicado: (2022)

Approach to Pyrido[2,1-b][1,3]benzothiazol-1-ones via In Situ Generation of Acyl(1,3-benzothiazol-2-yl)ketenes by Thermolysis of Pyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones
por: Lystsova, Ekaterina A., et al.
Publicado: (2023)

Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition
por: Dumitrascu, Florea, et al.
Publicado: (2013)

Phenyl(pyrrolo[2,1-a]isoquinolin-3-yl)methanone
por: Liu, Yun, et al.
Publicado: (2010)

1,2-Bis[1-(3-methylsulfanyl-1,2,4-triazin-5-yl)ethylidene]diazane
por: Mojzych, Mariusz, et al.
Publicado: (2009)

Synthesis of imidazo[4,5-e][1,3]thiazino[2,3-c][1,2,4]triazines via a base-induced rearrangement of functionalized imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazines
por: Vinogradov, Dmitry B, et al.
Publicado: (2023)

General Synthesis of 1-Aryl-6-azaisocytosines and Their Utilization for the Preparation of Related Condensed 1,2,4-Triazines
por: Zálešák, František, et al.
Publicado: (2019)

Isoxazolyl-Derived 1,4-Dihydroazolo[5,1-c][1,2,4]Triazines: Synthesis and Photochemical Properties
por: Sadchikova, Elena V., et al.
Publicado: (2023)

3-Methyl-1H-pyrrolo[2,1-c][1,4]oxazin-1-one
por: Khan, Salman Tariq, et al.
Publicado: (2010)

3-Phenyl-1H-pyrrolo[2,1-c][1,4]oxazin-1-one
por: Khan, Salman Tariq, et al.
Publicado: (2010)

Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
por: Bernat, Zofia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qh1gjcd2o2h7vmlbde31b54r9g