The impact of Gag non-cleavage site mutations on HIV-1 viral fitness from integrative modelling and simulations

The high mutation rate in retroviruses is one of the leading causes of drug resistance. In human immunodeficiency virus type-1 (HIV-1), synergistic mutations in its protease and the protease substrate – the Group-specific antigen (Gag) polyprotein – work together to confer drug resistance against pr...

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Detalles Bibliográficos
Autores principales: Samsudin, Firdaus, Gan, Samuel Ken-En, Bond, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779841/
https://www.ncbi.nlm.nih.gov/pubmed/33425260
http://dx.doi.org/10.1016/j.csbj.2020.12.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779841/
https://www.ncbi.nlm.nih.gov/pubmed/33425260
http://dx.doi.org/10.1016/j.csbj.2020.12.022

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