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Formation of Oxidatively Modified Lipids as the Basis for a Cellular Epilipidome
While often regarded as a subset of metabolomics, lipidomics can better be considered as a field in its own right. While the total number of lipid species in biology may not exceed the number of metabolites, they can be modified chemically and biochemically leading to an enormous diversity of deriva...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779974/ https://www.ncbi.nlm.nih.gov/pubmed/33408694 http://dx.doi.org/10.3389/fendo.2020.602771 |
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author | Spickett, Corinne M. |
author_facet | Spickett, Corinne M. |
author_sort | Spickett, Corinne M. |
collection | PubMed |
description | While often regarded as a subset of metabolomics, lipidomics can better be considered as a field in its own right. While the total number of lipid species in biology may not exceed the number of metabolites, they can be modified chemically and biochemically leading to an enormous diversity of derivatives, many of which retain the lipophilic properties of lipids and thus expand the lipidome greatly. Oxidative modification by radical oxygen species, either enzymatically or chemically, is one of the major mechanisms involved, although attack by non-radical oxidants also occurs. The modified lipids typically contain more oxygens in the form of hydroxyl, epoxide, carbonyl and carboxylic acid groups, and nitration, nitrosylation, halogenation or sulfation can also occur. This article provides a succinct overview of the types of species formed, the reactive compounds involved and the specific molecular sites that they react with, and the biochemical or chemical mechanisms involved. In many cases, these modifications reduce the stability of the lipid, and breakdown products are formed, which themselves have interesting properties such as the ability to react with other biomolecules. Publications on the biological effects of modified lipids are growing rapidly, supporting the concept that some of these biomolecules have potential signaling and regulatory effects. The question therefore arises whether modified lipids represent an “epilipidome”, analogous to the epigenetic modifications that can control gene expression. |
format | Online Article Text |
id | pubmed-7779974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77799742021-01-05 Formation of Oxidatively Modified Lipids as the Basis for a Cellular Epilipidome Spickett, Corinne M. Front Endocrinol (Lausanne) Endocrinology While often regarded as a subset of metabolomics, lipidomics can better be considered as a field in its own right. While the total number of lipid species in biology may not exceed the number of metabolites, they can be modified chemically and biochemically leading to an enormous diversity of derivatives, many of which retain the lipophilic properties of lipids and thus expand the lipidome greatly. Oxidative modification by radical oxygen species, either enzymatically or chemically, is one of the major mechanisms involved, although attack by non-radical oxidants also occurs. The modified lipids typically contain more oxygens in the form of hydroxyl, epoxide, carbonyl and carboxylic acid groups, and nitration, nitrosylation, halogenation or sulfation can also occur. This article provides a succinct overview of the types of species formed, the reactive compounds involved and the specific molecular sites that they react with, and the biochemical or chemical mechanisms involved. In many cases, these modifications reduce the stability of the lipid, and breakdown products are formed, which themselves have interesting properties such as the ability to react with other biomolecules. Publications on the biological effects of modified lipids are growing rapidly, supporting the concept that some of these biomolecules have potential signaling and regulatory effects. The question therefore arises whether modified lipids represent an “epilipidome”, analogous to the epigenetic modifications that can control gene expression. Frontiers Media S.A. 2020-12-21 /pmc/articles/PMC7779974/ /pubmed/33408694 http://dx.doi.org/10.3389/fendo.2020.602771 Text en Copyright © 2020 Spickett http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Spickett, Corinne M. Formation of Oxidatively Modified Lipids as the Basis for a Cellular Epilipidome |
title | Formation of Oxidatively Modified Lipids as the Basis for a Cellular Epilipidome |
title_full | Formation of Oxidatively Modified Lipids as the Basis for a Cellular Epilipidome |
title_fullStr | Formation of Oxidatively Modified Lipids as the Basis for a Cellular Epilipidome |
title_full_unstemmed | Formation of Oxidatively Modified Lipids as the Basis for a Cellular Epilipidome |
title_short | Formation of Oxidatively Modified Lipids as the Basis for a Cellular Epilipidome |
title_sort | formation of oxidatively modified lipids as the basis for a cellular epilipidome |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779974/ https://www.ncbi.nlm.nih.gov/pubmed/33408694 http://dx.doi.org/10.3389/fendo.2020.602771 |
work_keys_str_mv | AT spickettcorinnem formationofoxidativelymodifiedlipidsasthebasisforacellularepilipidome |