dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells

Deficiency in DNA repair proteins confers susceptibility to DNA damage, making cancer cells vulnerable to various cancer chemotherapies. 5‐Fluorouracil (5‐FU) is an anticancer nucleoside analog that both inhibits thymidylate synthase (TS) and causes DNA damage via the misincorporation of FdUTP and d...

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Detalles Bibliográficos
Autores principales: Yokogawa, Tatsushi, Yano, Wakako, Tsukioka, Sayaka, Osada, Akiko, Wakasa, Takeshi, Ueno, Hiroyuki, Hoshino, Takuya, Yamamura, Keisuke, Fujioka, Akio, Fukuoka, Masayoshi, Ohkubo, Shuichi, Matsuo, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Drug Discovery and Delivery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780055/
https://www.ncbi.nlm.nih.gov/pubmed/33140501
http://dx.doi.org/10.1111/cas.14718

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