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The Effect of Tryptophan 2,3-Dioxygenase Inhibition on Kynurenine Metabolism and Cognitive Function in the APP23 Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is associated with progressive endogenous neurotoxicity and hampered inflammatory regulation. The kynurenine (Kyn) pathway, which is controlled by tryptophan 2,3-dioxygenase (TDO), produces neuroactive and anti-inflammatory metabolites. Age-related Kyn pathway activation mig...

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Detalles Bibliográficos
Autores principales:	Sorgdrager, FJH, van Der Ley, CP, van Faassen, M, Calus, E, Nollen, EA, Kema, IP, van Dam, D, De Deyn, PP
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780178/ https://www.ncbi.nlm.nih.gov/pubmed/33447045 http://dx.doi.org/10.1177/1178646920972657

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