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Targeting CDK7 suppresses super enhancer-linked inflammatory genes and alleviates CAR T cell-induced cytokine release syndrome

BACKGROUND: Cytokine release syndrome (CRS) is a systemic inflammatory response characterized by the overexpression of inflammatory genes. Controlling CRS is essential for improving the therapeutic effects of chimeric antigen receptor (CAR) engineered T cells. However, current treatment options are...

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Detalles Bibliográficos
Autores principales:	Wei, Ye, Li, Chong, Bian, Huifang, Qian, Wei, Jin, Kairui, Xu, Tingting, Guo, Xiaomao, Lu, Xueguan, Su, Fengtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780220/ https://www.ncbi.nlm.nih.gov/pubmed/33397398 http://dx.doi.org/10.1186/s12943-020-01301-7

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