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Toward Respiratory Support of Critically Ill COVID-19 Patients Using Repurposed Kidney Hollow Fiber Membrane Dialysers to Oxygenate the Blood
The COVID-19 pandemic has highlighted resource constraints in respiratory support. The oxygen transfer characteristics of a specific hollow fiber membrane dialyser was investigated with a view to repurposing the device as a low-cost, readily available blood oxygenator. Oxygen transfer in a low-flux...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780225/ https://www.ncbi.nlm.nih.gov/pubmed/33425312 http://dx.doi.org/10.1155/2020/8862645 |
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author | Rubin, David M. Stacey, Neil T. Matambo, Tonderayi Vale, Claudia Do Sussman, Martin J. Snyman, Tracy Mer, Mervyn Hildebrandt, Diane |
author_facet | Rubin, David M. Stacey, Neil T. Matambo, Tonderayi Vale, Claudia Do Sussman, Martin J. Snyman, Tracy Mer, Mervyn Hildebrandt, Diane |
author_sort | Rubin, David M. |
collection | PubMed |
description | The COVID-19 pandemic has highlighted resource constraints in respiratory support. The oxygen transfer characteristics of a specific hollow fiber membrane dialyser was investigated with a view to repurposing the device as a low-cost, readily available blood oxygenator. Oxygen transfer in a low-flux hollow fiber dialyser with a polysulfone membrane was studied by passing first water and then blood through the dialyser in countercurrent to high-purity oxygen. Oxygen transfer rates of about 15% of the nominal 250 ml (STP)/min of a typical adult oxygen consumption rate were achieved for blood flow rates of 500 ml/min. Using two such dialysis devices in parallel could provide up to 30% of the nominal oxygen consumption. Specific hollow fiber dialysis devices operating with suitable pumps in a veno-venous access configuration could provide a cost-effective and readily available supplementation of respiratory support in the face of severe resource constraints. |
format | Online Article Text |
id | pubmed-7780225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-77802252021-01-08 Toward Respiratory Support of Critically Ill COVID-19 Patients Using Repurposed Kidney Hollow Fiber Membrane Dialysers to Oxygenate the Blood Rubin, David M. Stacey, Neil T. Matambo, Tonderayi Vale, Claudia Do Sussman, Martin J. Snyman, Tracy Mer, Mervyn Hildebrandt, Diane J Healthc Eng Research Article The COVID-19 pandemic has highlighted resource constraints in respiratory support. The oxygen transfer characteristics of a specific hollow fiber membrane dialyser was investigated with a view to repurposing the device as a low-cost, readily available blood oxygenator. Oxygen transfer in a low-flux hollow fiber dialyser with a polysulfone membrane was studied by passing first water and then blood through the dialyser in countercurrent to high-purity oxygen. Oxygen transfer rates of about 15% of the nominal 250 ml (STP)/min of a typical adult oxygen consumption rate were achieved for blood flow rates of 500 ml/min. Using two such dialysis devices in parallel could provide up to 30% of the nominal oxygen consumption. Specific hollow fiber dialysis devices operating with suitable pumps in a veno-venous access configuration could provide a cost-effective and readily available supplementation of respiratory support in the face of severe resource constraints. Hindawi 2020-11-03 /pmc/articles/PMC7780225/ /pubmed/33425312 http://dx.doi.org/10.1155/2020/8862645 Text en Copyright © 2020 David M. Rubin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Rubin, David M. Stacey, Neil T. Matambo, Tonderayi Vale, Claudia Do Sussman, Martin J. Snyman, Tracy Mer, Mervyn Hildebrandt, Diane Toward Respiratory Support of Critically Ill COVID-19 Patients Using Repurposed Kidney Hollow Fiber Membrane Dialysers to Oxygenate the Blood |
title | Toward Respiratory Support of Critically Ill COVID-19 Patients Using Repurposed Kidney Hollow Fiber Membrane Dialysers to Oxygenate the Blood |
title_full | Toward Respiratory Support of Critically Ill COVID-19 Patients Using Repurposed Kidney Hollow Fiber Membrane Dialysers to Oxygenate the Blood |
title_fullStr | Toward Respiratory Support of Critically Ill COVID-19 Patients Using Repurposed Kidney Hollow Fiber Membrane Dialysers to Oxygenate the Blood |
title_full_unstemmed | Toward Respiratory Support of Critically Ill COVID-19 Patients Using Repurposed Kidney Hollow Fiber Membrane Dialysers to Oxygenate the Blood |
title_short | Toward Respiratory Support of Critically Ill COVID-19 Patients Using Repurposed Kidney Hollow Fiber Membrane Dialysers to Oxygenate the Blood |
title_sort | toward respiratory support of critically ill covid-19 patients using repurposed kidney hollow fiber membrane dialysers to oxygenate the blood |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780225/ https://www.ncbi.nlm.nih.gov/pubmed/33425312 http://dx.doi.org/10.1155/2020/8862645 |
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