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Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning

BACKGROUND: There is increasing research interest in using short-chain fatty acids (SCFAs) including butyrate as potential alternatives to antibiotic growth promoters in animal production. This study was conducted to evaluate the effects of supplementation of sodium butyrate (SB) in liquid feeds (mi...

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Autores principales: Liu, Wenhui, La, A. La Teng Zhu, Evans, Alexander, Gao, Shengtao, Yu, Zhongtang, Bu, Dengpan, Ma, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780688/
https://www.ncbi.nlm.nih.gov/pubmed/33397482
http://dx.doi.org/10.1186/s40104-020-00521-7
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author Liu, Wenhui
La, A. La Teng Zhu
Evans, Alexander
Gao, Shengtao
Yu, Zhongtang
Bu, Dengpan
Ma, Lu
author_facet Liu, Wenhui
La, A. La Teng Zhu
Evans, Alexander
Gao, Shengtao
Yu, Zhongtang
Bu, Dengpan
Ma, Lu
author_sort Liu, Wenhui
collection PubMed
description BACKGROUND: There is increasing research interest in using short-chain fatty acids (SCFAs) including butyrate as potential alternatives to antibiotic growth promoters in animal production. This study was conducted to evaluate the effects of supplementation of sodium butyrate (SB) in liquid feeds (milk, milk replacer, and the mixture of both) on the growth performance, rumen fermentation, and serum antioxidant capacity and immunoglobins in dairy calves before weaning. Forty healthy female Holstein calves (4-day-old, 40 ± 5 kg of body weight) were housed in individual hutches and randomly allocated to 1 of 4 treatment groups (n = 10 per group) using the RAND function in Excel. The control group was fed no SB (SB0), while the other three groups were supplemented with 15 (SB15), 30 (SB30), or 45 (SB45) g/d of SB mixed into liquid feeds offered. The calves were initially fed milk only (days 2 to 20), then a mixture of milk and milk replacer (days 21 to 23), and finally milk replacer only (days 24 to 60). RESULTS: The SB supplementation enhanced growth and improved feed conversion into body weight gain compared with the SB0 group, and the average daily gain increased quadratically with increasing SB supplementation. No significant effect on rumen pH; concentrations of NH(3)-N, individual and total VFAs; or acetate: propionate (A:P) ratio was found during the whole experimental period. Serum glutathione peroxidase activity increased linearly with the increased SB supplementation, while the serum concentration of maleic dialdehyde linearly decreased. Serum concentrations of immunoglobulin A, immunoglobulin G, or immunoglobulin M were not affected by the SB supplementation during the whole experimental period. CONCLUSIONS: Under the conditions of this study, SB supplementation improved growth performance and antioxidant function in pre-weaned dairy calves. We recommended 45 g/d as the optimal level of SB supplementation mixed into liquid feeds (milk or milk replacer) to improve the growth and antioxidant function of dairy calves before weaning.
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spelling pubmed-77806882021-01-05 Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning Liu, Wenhui La, A. La Teng Zhu Evans, Alexander Gao, Shengtao Yu, Zhongtang Bu, Dengpan Ma, Lu J Anim Sci Biotechnol Research BACKGROUND: There is increasing research interest in using short-chain fatty acids (SCFAs) including butyrate as potential alternatives to antibiotic growth promoters in animal production. This study was conducted to evaluate the effects of supplementation of sodium butyrate (SB) in liquid feeds (milk, milk replacer, and the mixture of both) on the growth performance, rumen fermentation, and serum antioxidant capacity and immunoglobins in dairy calves before weaning. Forty healthy female Holstein calves (4-day-old, 40 ± 5 kg of body weight) were housed in individual hutches and randomly allocated to 1 of 4 treatment groups (n = 10 per group) using the RAND function in Excel. The control group was fed no SB (SB0), while the other three groups were supplemented with 15 (SB15), 30 (SB30), or 45 (SB45) g/d of SB mixed into liquid feeds offered. The calves were initially fed milk only (days 2 to 20), then a mixture of milk and milk replacer (days 21 to 23), and finally milk replacer only (days 24 to 60). RESULTS: The SB supplementation enhanced growth and improved feed conversion into body weight gain compared with the SB0 group, and the average daily gain increased quadratically with increasing SB supplementation. No significant effect on rumen pH; concentrations of NH(3)-N, individual and total VFAs; or acetate: propionate (A:P) ratio was found during the whole experimental period. Serum glutathione peroxidase activity increased linearly with the increased SB supplementation, while the serum concentration of maleic dialdehyde linearly decreased. Serum concentrations of immunoglobulin A, immunoglobulin G, or immunoglobulin M were not affected by the SB supplementation during the whole experimental period. CONCLUSIONS: Under the conditions of this study, SB supplementation improved growth performance and antioxidant function in pre-weaned dairy calves. We recommended 45 g/d as the optimal level of SB supplementation mixed into liquid feeds (milk or milk replacer) to improve the growth and antioxidant function of dairy calves before weaning. BioMed Central 2021-01-04 /pmc/articles/PMC7780688/ /pubmed/33397482 http://dx.doi.org/10.1186/s40104-020-00521-7 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Liu, Wenhui
La, A. La Teng Zhu
Evans, Alexander
Gao, Shengtao
Yu, Zhongtang
Bu, Dengpan
Ma, Lu
Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning
title Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning
title_full Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning
title_fullStr Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning
title_full_unstemmed Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning
title_short Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning
title_sort supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780688/
https://www.ncbi.nlm.nih.gov/pubmed/33397482
http://dx.doi.org/10.1186/s40104-020-00521-7
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