Cargando…
Reference flow: reducing reference bias using multiple population genomes
Most sequencing data analyses start by aligning sequencing reads to a linear reference genome, but failure to account for genetic variation leads to reference bias and confounding of results downstream. Other approaches replace the linear reference with structures like graphs that can include geneti...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780692/ https://www.ncbi.nlm.nih.gov/pubmed/33397413 http://dx.doi.org/10.1186/s13059-020-02229-3 |