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Functions of CD169 positive macrophages in human diseases (Review)
CD169(+) macrophages are a unique type of macrophage subset that differ from M1 and M2 macrophages. CD169(+) macrophages are present in multiple tissues and organs throughout the body and are primarily expressed in secondary lymphoid organs. These cells are primarily divided across three locations i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780751/ https://www.ncbi.nlm.nih.gov/pubmed/33408860 http://dx.doi.org/10.3892/br.2020.1402 |
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author | Liu, Yu Xia, Yuan Qiu, Chun-Hong |
author_facet | Liu, Yu Xia, Yuan Qiu, Chun-Hong |
author_sort | Liu, Yu |
collection | PubMed |
description | CD169(+) macrophages are a unique type of macrophage subset that differ from M1 and M2 macrophages. CD169(+) macrophages are present in multiple tissues and organs throughout the body and are primarily expressed in secondary lymphoid organs. These cells are primarily divided across three locations in secondary lymphoid organs: The metallophilic marginal zone of the spleen, the subcapsular sinus and the medulla of the lymph nodes. Due to their unique location distribution in vivo and the presence of the CD169 molecule on their surfaces, CD169(+) macrophages are reported to serve important roles in several processes, such as phagocytosis, antigen presentation, immune tolerance, viral infection and inflammatory responses. At the same time, it has been reported that CD169(+) macrophages may also serve an important role in anti-tumour immunity. The present review focuses on the research progress surrounding the function of CD169(+) macrophages in a variety of diseases, such as viral infection, autoimmune diseases and tumours. |
format | Online Article Text |
id | pubmed-7780751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-77807512021-01-05 Functions of CD169 positive macrophages in human diseases (Review) Liu, Yu Xia, Yuan Qiu, Chun-Hong Biomed Rep Review CD169(+) macrophages are a unique type of macrophage subset that differ from M1 and M2 macrophages. CD169(+) macrophages are present in multiple tissues and organs throughout the body and are primarily expressed in secondary lymphoid organs. These cells are primarily divided across three locations in secondary lymphoid organs: The metallophilic marginal zone of the spleen, the subcapsular sinus and the medulla of the lymph nodes. Due to their unique location distribution in vivo and the presence of the CD169 molecule on their surfaces, CD169(+) macrophages are reported to serve important roles in several processes, such as phagocytosis, antigen presentation, immune tolerance, viral infection and inflammatory responses. At the same time, it has been reported that CD169(+) macrophages may also serve an important role in anti-tumour immunity. The present review focuses on the research progress surrounding the function of CD169(+) macrophages in a variety of diseases, such as viral infection, autoimmune diseases and tumours. D.A. Spandidos 2021-02 2020-12-17 /pmc/articles/PMC7780751/ /pubmed/33408860 http://dx.doi.org/10.3892/br.2020.1402 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Liu, Yu Xia, Yuan Qiu, Chun-Hong Functions of CD169 positive macrophages in human diseases (Review) |
title | Functions of CD169 positive macrophages in human diseases (Review) |
title_full | Functions of CD169 positive macrophages in human diseases (Review) |
title_fullStr | Functions of CD169 positive macrophages in human diseases (Review) |
title_full_unstemmed | Functions of CD169 positive macrophages in human diseases (Review) |
title_short | Functions of CD169 positive macrophages in human diseases (Review) |
title_sort | functions of cd169 positive macrophages in human diseases (review) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780751/ https://www.ncbi.nlm.nih.gov/pubmed/33408860 http://dx.doi.org/10.3892/br.2020.1402 |
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