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The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism
INTRODUCTION: Vitamin D deficiency is a global health problem. Its deficiency has been reported to be associated with different autoimmune diseases. AIM: The aim of this study was to evaluate the relationship between vitamin D level and thyroid antibodies in autoimmune hypothyroidism. METHODS: A tot...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Academy of Medical Sciences of Bosnia and Herzegovina
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780811/ https://www.ncbi.nlm.nih.gov/pubmed/33424090 http://dx.doi.org/10.5455/medarh.2020.74.359-362 |
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author | Sulejmanovic, Maja Begić, Amela Mujaric-Bousbia, Fatima Salkic, Sabina Ramas, Almedina |
author_facet | Sulejmanovic, Maja Begić, Amela Mujaric-Bousbia, Fatima Salkic, Sabina Ramas, Almedina |
author_sort | Sulejmanovic, Maja |
collection | PubMed |
description | INTRODUCTION: Vitamin D deficiency is a global health problem. Its deficiency has been reported to be associated with different autoimmune diseases. AIM: The aim of this study was to evaluate the relationship between vitamin D level and thyroid antibodies in autoimmune hypothyroidism. METHODS: A total number of 150 individuals were enrolled in this study. They were divided into the fallowing groups: group I included 50 patients with autoimmune thyroid disease (AITD), group II included 50 patients without autoimmune thyroid disease. Group III included 50 apparently healthy participants representing a control group. All participants underwent a detailed clinical examination and laboratory tests including, 25 (OH) vitamin D, thyroid-stimulating hormone (TSH) and thyroid autoantibodies assessment, including anti-thyroid peroxidase antibodies (anti-TPO) and anti-thyroglobulin antibodies (anti-TG). RESULTS: Serum levels of 25 (OH) vitamin D recorded a highly significant difference between the studies groups (20,76±6,31 ng/ml in group I vs. 24,37±9,05ng/ml in group II vs. 24,57±6,45ng/ml in group III, p<0,01). Moreover, there was a highly significant difference between patients with AITD and patients without AITD (20,76±6,31ng/ml vs. 24,37±9,05ng/ml, respectively; p<0,01). The concentration of anti-TPO and anti-TG antibodies were statistically significant higher in patients with vitamin D deficiency (p< 0,001). Serum TSH were significantly higher in group I (p< 0,001). CONCLUSION: Significantly low levels of vitamin D were documented in patients with AITD that were related to the presence of anti-thyroid antibodies and higher level thyroid-stimulation hormone (TSH), suggesting the involvement of vitamin D in the pathogenesis of AITD and the advisability of supplementation. |
format | Online Article Text |
id | pubmed-7780811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Academy of Medical Sciences of Bosnia and Herzegovina |
record_format | MEDLINE/PubMed |
spelling | pubmed-77808112021-01-07 The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism Sulejmanovic, Maja Begić, Amela Mujaric-Bousbia, Fatima Salkic, Sabina Ramas, Almedina Med Arch Original Paper INTRODUCTION: Vitamin D deficiency is a global health problem. Its deficiency has been reported to be associated with different autoimmune diseases. AIM: The aim of this study was to evaluate the relationship between vitamin D level and thyroid antibodies in autoimmune hypothyroidism. METHODS: A total number of 150 individuals were enrolled in this study. They were divided into the fallowing groups: group I included 50 patients with autoimmune thyroid disease (AITD), group II included 50 patients without autoimmune thyroid disease. Group III included 50 apparently healthy participants representing a control group. All participants underwent a detailed clinical examination and laboratory tests including, 25 (OH) vitamin D, thyroid-stimulating hormone (TSH) and thyroid autoantibodies assessment, including anti-thyroid peroxidase antibodies (anti-TPO) and anti-thyroglobulin antibodies (anti-TG). RESULTS: Serum levels of 25 (OH) vitamin D recorded a highly significant difference between the studies groups (20,76±6,31 ng/ml in group I vs. 24,37±9,05ng/ml in group II vs. 24,57±6,45ng/ml in group III, p<0,01). Moreover, there was a highly significant difference between patients with AITD and patients without AITD (20,76±6,31ng/ml vs. 24,37±9,05ng/ml, respectively; p<0,01). The concentration of anti-TPO and anti-TG antibodies were statistically significant higher in patients with vitamin D deficiency (p< 0,001). Serum TSH were significantly higher in group I (p< 0,001). CONCLUSION: Significantly low levels of vitamin D were documented in patients with AITD that were related to the presence of anti-thyroid antibodies and higher level thyroid-stimulation hormone (TSH), suggesting the involvement of vitamin D in the pathogenesis of AITD and the advisability of supplementation. Academy of Medical Sciences of Bosnia and Herzegovina 2020-10 /pmc/articles/PMC7780811/ /pubmed/33424090 http://dx.doi.org/10.5455/medarh.2020.74.359-362 Text en © 2020 Maja Sulejmanovic, Amra Jakubovic-Cickusic, Amela Begic, Fatima Mujaric-Bousbia, Sabina Salkic, Almedina Ramas http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Sulejmanovic, Maja Begić, Amela Mujaric-Bousbia, Fatima Salkic, Sabina Ramas, Almedina The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism |
title | The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism |
title_full | The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism |
title_fullStr | The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism |
title_full_unstemmed | The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism |
title_short | The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism |
title_sort | relationship between thyroid antibodies and vitamin d level in primary hypothyroidism |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780811/ https://www.ncbi.nlm.nih.gov/pubmed/33424090 http://dx.doi.org/10.5455/medarh.2020.74.359-362 |
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