Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity

Transgenic animals incorporating human antibody genes are extremely attractive for drug development because they obviate subsequent antibody humanization procedures required for therapeutic translation. Transgenic platforms have previously been established using mice, but also more recently rats, ch...

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Detalles Bibliográficos
Autores principales: Ros, Francesca, Offner, Sonja, Klostermann, Stefan, Thorey, Irmgard, Niersbach, Helmut, Breuer, Sebastian, Zarnt, Grit, Lorenz, Stefan, Puels, Juergen, Siewe, Basile, Schueler, Nicole, Dragicevic, Tajana, Ostler, Dominique, Hansen-Wester, Imke, Lifke, Valeria, Kaluza, Brigitte, Kaluza, Klaus, van Schooten, Wim, Buelow, Roland, Tissot, Alain C, Platzer, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780963/
https://www.ncbi.nlm.nih.gov/pubmed/33228444
http://dx.doi.org/10.1080/19420862.2020.1846900

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