Urinary Leukotriene E(4) and Prostaglandin D(2) Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

Rationale: New approaches are needed to guide personalized treatment of asthma. Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: Urinary metabolites of prostaglandins (PGs), cysteinyl leukotrienes (CysLTs), and isoprostanes were quantified in the U-BIOPRE...

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Detalles Bibliográficos
Autores principales: Kolmert, Johan, Gómez, Cristina, Balgoma, David, Sjödin, Marcus, Bood, Johan, Konradsen, Jon R., Ericsson, Magnus, Thörngren, John-Olof, James, Anna, Mikus, Maria, Sousa, Ana R., Riley, John H., Bates, Stewart, Bakke, Per S., Pandis, Ioannis, Caruso, Massimo, Chanez, Pascal, Fowler, Stephen J., Geiser, Thomas, Howarth, Peter, Horváth, Ildikó, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Behndig, Annelie, Shaw, Dominick E., Knowles, Richard G., Holweg, Cécile T. J., Wheelock, Åsa M., Dahlén, Barbro, Nordlund, Björn, Alving, Kjell, Hedlin, Gunilla, Chung, Kian Fan, Adcock, Ian M., Sterk, Peter J., Djukanovic, Ratko, Dahlén, Sven-Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Thoracic Society 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781128/
https://www.ncbi.nlm.nih.gov/pubmed/32667261
http://dx.doi.org/10.1164/rccm.201909-1869OC

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