Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review

Pancreatic adenocarcinoma has a poor 5-year survival rate despite many advancements in pharmacotherapies. Studies have suggested the involvement of β-adrenergic pathway in the progression of pancreatic adenocarcinoma. Animal experiments and retrospective trials have reported the use of beta-blockers...

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Autores principales: Upadhyaya, Vandan D., Douedi, Steven, Garcia, Brandon, Gonzalez, Jimmy, Udongwo, Ndausung, Wei, Juanqin, Nai, Qiang, Asif, Arif, Sen, Shuvendu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781287/
https://www.ncbi.nlm.nih.gov/pubmed/33447308
http://dx.doi.org/10.14740/jocmr4387
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author Upadhyaya, Vandan D.
Douedi, Steven
Garcia, Brandon
Gonzalez, Jimmy
Udongwo, Ndausung
Wei, Juanqin
Nai, Qiang
Asif, Arif
Sen, Shuvendu
author_facet Upadhyaya, Vandan D.
Douedi, Steven
Garcia, Brandon
Gonzalez, Jimmy
Udongwo, Ndausung
Wei, Juanqin
Nai, Qiang
Asif, Arif
Sen, Shuvendu
author_sort Upadhyaya, Vandan D.
collection PubMed
description Pancreatic adenocarcinoma has a poor 5-year survival rate despite many advancements in pharmacotherapies. Studies have suggested the involvement of β-adrenergic pathway in the progression of pancreatic adenocarcinoma. Animal experiments and retrospective trials have reported the use of beta-blockers as potential chemo-preventative agents. This review aims to discuss β-adrenergic physiology as it relates to the progression of pancreatic adenocarcinoma and review outcomes on the use of beta-blockers for its treatment.
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spelling pubmed-77812872021-01-13 Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review Upadhyaya, Vandan D. Douedi, Steven Garcia, Brandon Gonzalez, Jimmy Udongwo, Ndausung Wei, Juanqin Nai, Qiang Asif, Arif Sen, Shuvendu J Clin Med Res Review Pancreatic adenocarcinoma has a poor 5-year survival rate despite many advancements in pharmacotherapies. Studies have suggested the involvement of β-adrenergic pathway in the progression of pancreatic adenocarcinoma. Animal experiments and retrospective trials have reported the use of beta-blockers as potential chemo-preventative agents. This review aims to discuss β-adrenergic physiology as it relates to the progression of pancreatic adenocarcinoma and review outcomes on the use of beta-blockers for its treatment. Elmer Press 2020-12 2020-12-18 /pmc/articles/PMC7781287/ /pubmed/33447308 http://dx.doi.org/10.14740/jocmr4387 Text en Copyright 2020, Upadhyaya et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Upadhyaya, Vandan D.
Douedi, Steven
Garcia, Brandon
Gonzalez, Jimmy
Udongwo, Ndausung
Wei, Juanqin
Nai, Qiang
Asif, Arif
Sen, Shuvendu
Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review
title Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review
title_full Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review
title_fullStr Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review
title_full_unstemmed Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review
title_short Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review
title_sort mechanism and effect of beta-blockers on pancreatic adenocarcinoma: a literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781287/
https://www.ncbi.nlm.nih.gov/pubmed/33447308
http://dx.doi.org/10.14740/jocmr4387
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