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Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia
In some patients, migraine attacks are associated with symptoms of allodynia which can be localized (cephalic) or generalized (extracephalic). Using functional neuroimaging and cutaneous thermal stimulation, we aimed to investigate the differences in brain activation of patients with episodic migrai...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781392/ https://www.ncbi.nlm.nih.gov/pubmed/33395413 http://dx.doi.org/10.1371/journal.pone.0244320 |
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author | Maleki, Nasim Szabo, Edina Becerra, Lino Moulton, Eric Scrivani, Steven J. Burstein, Rami Borsook, David |
author_facet | Maleki, Nasim Szabo, Edina Becerra, Lino Moulton, Eric Scrivani, Steven J. Burstein, Rami Borsook, David |
author_sort | Maleki, Nasim |
collection | PubMed |
description | In some patients, migraine attacks are associated with symptoms of allodynia which can be localized (cephalic) or generalized (extracephalic). Using functional neuroimaging and cutaneous thermal stimulation, we aimed to investigate the differences in brain activation of patients with episodic migraine (n = 19) based on their allodynic status defined by changes between ictal and interictal pain tolerance threshold for each subject at the time of imaging. In this prospective imaging study, differences were found in brain activity between the ictal and interictal visits in the brainstem/pons, thalamus, insula, cerebellum and cingulate cortex. Significant differences were also observed in the pattern of activation along the trigeminal pathway to noxious heat stimuli in no allodynia vs. generalized allodynia in the thalamus and the trigeminal nucleus but there were no activation differences in the trigeminal ganglion. The functional magnetic resonance imaging (fMRI) findings provide direct evidence for the view that in migraine patients who are allodynic during the ictal phase of their attacks, the spinal trigeminal nucleus and posterior thalamus become hyper-responsive (sensitized)–to the extent that they mediate cephalic and extracephalic allodynia, respectively. In addition, descending analgesic systems seem as “switched off” in generalized allodynia. |
format | Online Article Text |
id | pubmed-7781392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77813922021-01-07 Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia Maleki, Nasim Szabo, Edina Becerra, Lino Moulton, Eric Scrivani, Steven J. Burstein, Rami Borsook, David PLoS One Research Article In some patients, migraine attacks are associated with symptoms of allodynia which can be localized (cephalic) or generalized (extracephalic). Using functional neuroimaging and cutaneous thermal stimulation, we aimed to investigate the differences in brain activation of patients with episodic migraine (n = 19) based on their allodynic status defined by changes between ictal and interictal pain tolerance threshold for each subject at the time of imaging. In this prospective imaging study, differences were found in brain activity between the ictal and interictal visits in the brainstem/pons, thalamus, insula, cerebellum and cingulate cortex. Significant differences were also observed in the pattern of activation along the trigeminal pathway to noxious heat stimuli in no allodynia vs. generalized allodynia in the thalamus and the trigeminal nucleus but there were no activation differences in the trigeminal ganglion. The functional magnetic resonance imaging (fMRI) findings provide direct evidence for the view that in migraine patients who are allodynic during the ictal phase of their attacks, the spinal trigeminal nucleus and posterior thalamus become hyper-responsive (sensitized)–to the extent that they mediate cephalic and extracephalic allodynia, respectively. In addition, descending analgesic systems seem as “switched off” in generalized allodynia. Public Library of Science 2021-01-04 /pmc/articles/PMC7781392/ /pubmed/33395413 http://dx.doi.org/10.1371/journal.pone.0244320 Text en © 2021 Maleki et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Maleki, Nasim Szabo, Edina Becerra, Lino Moulton, Eric Scrivani, Steven J. Burstein, Rami Borsook, David Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia |
title | Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia |
title_full | Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia |
title_fullStr | Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia |
title_full_unstemmed | Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia |
title_short | Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia |
title_sort | ictal and interictal brain activation in episodic migraine: neural basis for extent of allodynia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781392/ https://www.ncbi.nlm.nih.gov/pubmed/33395413 http://dx.doi.org/10.1371/journal.pone.0244320 |
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