No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis

BACKGROUND: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arterit...

Descripción completa

Detalles Bibliográficos
Autores principales: Verdijk, Robert M, Ouwendijk, Werner J D, Kuijpers, Robert W A M, Verjans, Georges M G M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781446/
https://www.ncbi.nlm.nih.gov/pubmed/32901261
http://dx.doi.org/10.1093/infdis/jiaa566
_version_ 1783631680109543424
author Verdijk, Robert M
Ouwendijk, Werner J D
Kuijpers, Robert W A M
Verjans, Georges M G M
author_facet Verdijk, Robert M
Ouwendijk, Werner J D
Kuijpers, Robert W A M
Verjans, Georges M G M
author_sort Verdijk, Robert M
collection PubMed
description BACKGROUND: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis. METHODS: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E. RESULTS: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections. CONCLUSIONS: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.
format Online
Article
Text
id pubmed-7781446
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-77814462021-01-07 No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis Verdijk, Robert M Ouwendijk, Werner J D Kuijpers, Robert W A M Verjans, Georges M G M J Infect Dis Major Articles and Brief Reports BACKGROUND: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis. METHODS: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E. RESULTS: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections. CONCLUSIONS: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis. Oxford University Press 2020-09-09 /pmc/articles/PMC7781446/ /pubmed/32901261 http://dx.doi.org/10.1093/infdis/jiaa566 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
Verdijk, Robert M
Ouwendijk, Werner J D
Kuijpers, Robert W A M
Verjans, Georges M G M
No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis
title No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis
title_full No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis
title_fullStr No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis
title_full_unstemmed No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis
title_short No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis
title_sort no evidence of varicella-zoster virus infection in temporal artery biopsies of anterior ischemic optic neuropathy patients with and without giant cell arteritis
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781446/
https://www.ncbi.nlm.nih.gov/pubmed/32901261
http://dx.doi.org/10.1093/infdis/jiaa566
work_keys_str_mv AT verdijkrobertm noevidenceofvaricellazostervirusinfectionintemporalarterybiopsiesofanteriorischemicopticneuropathypatientswithandwithoutgiantcellarteritis
AT ouwendijkwernerjd noevidenceofvaricellazostervirusinfectionintemporalarterybiopsiesofanteriorischemicopticneuropathypatientswithandwithoutgiantcellarteritis
AT kuijpersrobertwam noevidenceofvaricellazostervirusinfectionintemporalarterybiopsiesofanteriorischemicopticneuropathypatientswithandwithoutgiantcellarteritis
AT verjansgeorgesmgm noevidenceofvaricellazostervirusinfectionintemporalarterybiopsiesofanteriorischemicopticneuropathypatientswithandwithoutgiantcellarteritis

Ejemplares similares