Germline MBD4 Mutations and Predisposition to Uveal Melanoma

BACKGROUND: Uveal melanoma (UM) arises from malignant transformation of melanocytes in the uveal tract of the eye. This rare tumor has a poor outcome with frequent chemo-resistant liver metastases. BAP1 is the only known predisposing gene for UM. UMs are generally characterized by low tumor mutation...

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Detalles Bibliográficos
Autores principales: Derrien, Anne-Céline, Rodrigues, Manuel, Eeckhoutte, Alexandre, Dayot, Stéphane, Houy, Alexandre, Mobuchon, Lenha, Gardrat, Sophie, Lequin, Delphine, Ballet, Stelly, Pierron, Gaëlle, Alsafadi, Samar, Mariani, Odette, El-Marjou, Ahmed, Matet, Alexandre, Colas, Chrystelle, Cassoux, Nathalie, Stern, Marc-Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781447/
https://www.ncbi.nlm.nih.gov/pubmed/32239153
http://dx.doi.org/10.1093/jnci/djaa047

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