Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

The giant muscle protein titin is a major contributor to passive force; however, its role in active force generation is unresolved. Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quantify how titin-based forces define myocyte ultrastru...

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Detalles Bibliográficos
Autores principales: Li, Yong, Hessel, Anthony L, Unger, Andreas, Ing, David, Recker, Jannik, Koser, Franziska, Freundt, Johanna K, Linke, Wolfgang A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781594/
https://www.ncbi.nlm.nih.gov/pubmed/33357376
http://dx.doi.org/10.7554/eLife.64107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781594/
https://www.ncbi.nlm.nih.gov/pubmed/33357376
http://dx.doi.org/10.7554/eLife.64107

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