A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer’s disease, Down syndrome, and TBC1D24-associated epilepsy, while also loss-of-function mutations in Synj1 ar...

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Detalles Bibliográficos
Autores principales: Paesmans, Jone, Martin, Ella, Deckers, Babette, Berghmans, Marjolijn, Sethi, Ritika, Loeys, Yannick, Pardon, Els, Steyaert, Jan, Verstreken, Patrik, Galicia, Christian, Versées, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781601/
https://www.ncbi.nlm.nih.gov/pubmed/33349335
http://dx.doi.org/10.7554/eLife.64922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781601/
https://www.ncbi.nlm.nih.gov/pubmed/33349335
http://dx.doi.org/10.7554/eLife.64922

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