Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway

Chimeric antigen receptor T (CAR-T) cell therapy has been applied successfully in treating hematologic malignancies; however, it shows very limited efficacy in treating solid tumors. Adenosine is one of the key immunosuppressive metabolites in tumor microenvironment (TME) of solid tumors. Although t...

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Detalles Bibliográficos
Autores principales: Li, Na, Tang, Na, Cheng, Chen, Hu, Tao, Wei, Xiaofei, Han, Weidong, Wang, Haoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781731/
https://www.ncbi.nlm.nih.gov/pubmed/33457103
http://dx.doi.org/10.1080/2162402X.2020.1824643

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