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Immunotherapy with NK cells: recent developments in gene modification open up new avenues
Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual kill...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781759/ https://www.ncbi.nlm.nih.gov/pubmed/33457093 http://dx.doi.org/10.1080/2162402X.2020.1777651 |
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author | Reindl, Lisa Marie Albinger, Nawid Bexte, Tobias Müller, Stephan Hartmann, Jessica Ullrich, Evelyn |
author_facet | Reindl, Lisa Marie Albinger, Nawid Bexte, Tobias Müller, Stephan Hartmann, Jessica Ullrich, Evelyn |
author_sort | Reindl, Lisa Marie |
collection | PubMed |
description | Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies worldwide. This review illuminates the current state of research and clinical application of CAR-NK cells, as well as future developmental potential. |
format | Online Article Text |
id | pubmed-7781759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-77817592021-01-14 Immunotherapy with NK cells: recent developments in gene modification open up new avenues Reindl, Lisa Marie Albinger, Nawid Bexte, Tobias Müller, Stephan Hartmann, Jessica Ullrich, Evelyn Oncoimmunology Review Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies worldwide. This review illuminates the current state of research and clinical application of CAR-NK cells, as well as future developmental potential. Taylor & Francis 2020-09-02 /pmc/articles/PMC7781759/ /pubmed/33457093 http://dx.doi.org/10.1080/2162402X.2020.1777651 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Reindl, Lisa Marie Albinger, Nawid Bexte, Tobias Müller, Stephan Hartmann, Jessica Ullrich, Evelyn Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
title | Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
title_full | Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
title_fullStr | Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
title_full_unstemmed | Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
title_short | Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
title_sort | immunotherapy with nk cells: recent developments in gene modification open up new avenues |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781759/ https://www.ncbi.nlm.nih.gov/pubmed/33457093 http://dx.doi.org/10.1080/2162402X.2020.1777651 |
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