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Immunotherapy with NK cells: recent developments in gene modification open up new avenues

Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual kill...

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Detalles Bibliográficos
Autores principales: Reindl, Lisa Marie, Albinger, Nawid, Bexte, Tobias, Müller, Stephan, Hartmann, Jessica, Ullrich, Evelyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781759/
https://www.ncbi.nlm.nih.gov/pubmed/33457093
http://dx.doi.org/10.1080/2162402X.2020.1777651
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author Reindl, Lisa Marie
Albinger, Nawid
Bexte, Tobias
Müller, Stephan
Hartmann, Jessica
Ullrich, Evelyn
author_facet Reindl, Lisa Marie
Albinger, Nawid
Bexte, Tobias
Müller, Stephan
Hartmann, Jessica
Ullrich, Evelyn
author_sort Reindl, Lisa Marie
collection PubMed
description Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies worldwide. This review illuminates the current state of research and clinical application of CAR-NK cells, as well as future developmental potential.
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spelling pubmed-77817592021-01-14 Immunotherapy with NK cells: recent developments in gene modification open up new avenues Reindl, Lisa Marie Albinger, Nawid Bexte, Tobias Müller, Stephan Hartmann, Jessica Ullrich, Evelyn Oncoimmunology Review Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies worldwide. This review illuminates the current state of research and clinical application of CAR-NK cells, as well as future developmental potential. Taylor & Francis 2020-09-02 /pmc/articles/PMC7781759/ /pubmed/33457093 http://dx.doi.org/10.1080/2162402X.2020.1777651 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Reindl, Lisa Marie
Albinger, Nawid
Bexte, Tobias
Müller, Stephan
Hartmann, Jessica
Ullrich, Evelyn
Immunotherapy with NK cells: recent developments in gene modification open up new avenues
title Immunotherapy with NK cells: recent developments in gene modification open up new avenues
title_full Immunotherapy with NK cells: recent developments in gene modification open up new avenues
title_fullStr Immunotherapy with NK cells: recent developments in gene modification open up new avenues
title_full_unstemmed Immunotherapy with NK cells: recent developments in gene modification open up new avenues
title_short Immunotherapy with NK cells: recent developments in gene modification open up new avenues
title_sort immunotherapy with nk cells: recent developments in gene modification open up new avenues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781759/
https://www.ncbi.nlm.nih.gov/pubmed/33457093
http://dx.doi.org/10.1080/2162402X.2020.1777651
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