The Hidden Variable: A Case of Dasatinib-Induced Respiratory Failure

Tyrosine kinase inhibitors that target the BCR/ABL mutation have been used as therapies of BCR/ABL positive acute lymphoblastic leukemia (ALL) with significant results. Dasatinib is a multitargeted tyrosine kinase inhibitor with significant activity in Philadephia positive ALL which is resistant to...

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Detalles Bibliográficos
Autores principales: Drekolias, Dimitrios, Gadela, Naga Vaishnavi, Syeda, Asma, Jacob, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781781/
https://www.ncbi.nlm.nih.gov/pubmed/33415044
http://dx.doi.org/10.7759/cureus.11892
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author Drekolias, Dimitrios
Gadela, Naga Vaishnavi
Syeda, Asma
Jacob, Jason
author_facet Drekolias, Dimitrios
Gadela, Naga Vaishnavi
Syeda, Asma
Jacob, Jason
author_sort Drekolias, Dimitrios
collection PubMed
description Tyrosine kinase inhibitors that target the BCR/ABL mutation have been used as therapies of BCR/ABL positive acute lymphoblastic leukemia (ALL) with significant results. Dasatinib is a multitargeted tyrosine kinase inhibitor with significant activity in Philadephia positive ALL which is resistant to imatinib, as well as in treatment-naïve patients. We present a case of an elderly patient with Philadelphia chromosome-positive ALL, who presented with acute hypoxic respiratory failure in the setting of active immunotherapy with dasatinib.
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spelling pubmed-77817812021-01-06 The Hidden Variable: A Case of Dasatinib-Induced Respiratory Failure Drekolias, Dimitrios Gadela, Naga Vaishnavi Syeda, Asma Jacob, Jason Cureus Internal Medicine Tyrosine kinase inhibitors that target the BCR/ABL mutation have been used as therapies of BCR/ABL positive acute lymphoblastic leukemia (ALL) with significant results. Dasatinib is a multitargeted tyrosine kinase inhibitor with significant activity in Philadephia positive ALL which is resistant to imatinib, as well as in treatment-naïve patients. We present a case of an elderly patient with Philadelphia chromosome-positive ALL, who presented with acute hypoxic respiratory failure in the setting of active immunotherapy with dasatinib. Cureus 2020-12-04 /pmc/articles/PMC7781781/ /pubmed/33415044 http://dx.doi.org/10.7759/cureus.11892 Text en Copyright © 2020, Drekolias et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Drekolias, Dimitrios
Gadela, Naga Vaishnavi
Syeda, Asma
Jacob, Jason
The Hidden Variable: A Case of Dasatinib-Induced Respiratory Failure
title The Hidden Variable: A Case of Dasatinib-Induced Respiratory Failure
title_full The Hidden Variable: A Case of Dasatinib-Induced Respiratory Failure
title_fullStr The Hidden Variable: A Case of Dasatinib-Induced Respiratory Failure
title_full_unstemmed The Hidden Variable: A Case of Dasatinib-Induced Respiratory Failure
title_short The Hidden Variable: A Case of Dasatinib-Induced Respiratory Failure
title_sort hidden variable: a case of dasatinib-induced respiratory failure
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781781/
https://www.ncbi.nlm.nih.gov/pubmed/33415044
http://dx.doi.org/10.7759/cureus.11892
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